Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
 
next
study
previous
study
c19early.org COVID-19 treatment researchColchicineColchicine (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis       

Colchicine and/or Naltrexone for Hospitalized COVID-19 Patients Not Requiring High Levels of Ventilatory Support (COLTREXONE): A Prospective, Randomized, Open-Label Trial

Gertner et al., Cureus, doi:10.7759/cureus.60364, COLTREXONE, NCT04756128
May 2024  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
ICU/stepdown 65% Improvement Relative Risk Recovery 43% Day of recovery 24% primary HFNC/NIPPV 34% Hospitalization time 20% Colchicine  COLTREXONE  LATE TREATMENT  RCT Is late treatment with colchicine beneficial for COVID-19? RCT 137 patients in the USA (January - November 2021) Lower ICU admission (p=0.11) and improved recovery (p=0.14), not sig. c19early.org Gertner et al., Cureus, May 2024 Favorscolchicine Favorscontrol 0 0.5 1 1.5 2+
Colchicine for COVID-19
5th treatment shown to reduce risk in September 2020, now with p = 0.00000031 from 56 studies.
Lower risk for mortality, ICU, hospitalization, and recovery.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 111 treatments. c19early.org
Open-label RCT 137 hospitalized COVID-19 patients, showing lower progression to ICU/step-down ICU and improved recovery with colchicine, both without statistical significance. The primary outcome was changed mid-trial due to the low number of patients progressing to severe disease.
ICU/stepdown, 65.0% lower, OR 0.35, p = 0.11, treatment 67, control 70, adjusted per study, multivariable, RR approximated with OR.
recovery, 43.2% lower, OR 0.57, p = 0.14, treatment 67, control 70, adjusted per study, inverted to make OR<1 favor treatment, multivariable, day 5, RR approximated with OR.
day of recovery, 24.2% lower, HR 0.76, p = 0.12, treatment 67, control 70, adjusted per study, inverted to make HR<1 favor treatment, multivariable, Cox proportional hazards, primary outcome.
HFNC/NIPPV, 34.0% lower, OR 0.66, p = 0.34, treatment 67, control 70, adjusted per study, multivariable, RR approximated with OR.
hospitalization time, 20.0% lower, relative time 0.80, p = 0.13, treatment 67, control 70, adjusted per study, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Gertner et al., 15 May 2024, Randomized Controlled Trial, USA, peer-reviewed, mean age 58.0, 8 authors, study period 25 January, 2021 - 29 November, 2021, trial NCT04756128 (history) (COLTREXONE). Contact: elie.x.gertner@healthpartners.com.
This PaperColchicineAll
Colchicine and/or Naltrexone for Hospitalized COVID-19 Patients Not Requiring High Levels of Ventilatory Support (COLTREXONE): A Prospective, Randomized, Open-Label Trial
Elie Gertner, Anne Schullo-Feulner, Alison Knutson, Ella Chrenka, Meghan O'brien, Christine Behrendt, Joseph Johnson, Daniel Delaney
Cureus, doi:10.7759/cureus.60364
We assessed the efficacy and safety of colchicine and low-dose naltrexone (LDN), alone and in combination, in preventing progression to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In this prospective, randomized, open-label trial, colchicine and LDN were compared to standard of care (SOC) in patients hospitalized with SARS-CoV-2 not requiring high levels of ventilatory support. Patients were randomly assigned to colchicine alone, LDN alone, colchicine/LDN in combination, or SOC. The primary outcome was time to disease recovery. Secondary outcomes included total time hospitalized, study enrollment, level of care, oxygen support, and adverse events. One-hundred and thirty-seven patients were randomized (N c = 34, N c+ldn = 33, N ldn = 35, N soc = 35). Eightyfour patients (61%) achieved disease recovery by day 5. There was no significant difference in the proportion of patients who experienced the primary efficacy outcome among those who received colchicine, LDN, or between the four study arms. Patients receiving colchicine had a shorter length of enrollment but not a significant reduction in the length of stay. Diarrhea was the most common adverse reaction. In adults hospitalized with SARS-CoV-2 not requiring high-level ventilatory support, colchicine and LDN, alone and in combination, were not associated with significant reductions in progression to severe disease.
Additional Information Author Contributions All authors have reviewed the final version to be published and agreed to be accountable for all aspects of the work. Concept and design: Elie
References
Assaly, Olson, Hammersley, Fan, Liu et al., Initial evidence of endothelial cell apoptosis as a mechanism of systemic capillary leak syndrome, Chest, doi:10.1378/chest.120.4.1301
Bikdeli, Madhavan, Jimenez, COVID-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and follow-up: JACC state-of-the-art review, J Am Coll Cardiol, doi:10.1016/j.jacc.2020.04.031
Bonaventura, Vecchié, Dagna, Tangianu, Abbate et al., Colchicine for COVID-19: targeting NLRP3 inflammasome to blunt hyperinflammation, Inflamm Res, doi:10.1007/s00011-022-01540-y
Choubey, Dehury, Kumar, Medhi, Mondal, Naltrexone a potential therapeutic candidate for COVID-19, J Biomol Struct Dyn, doi:10.1080/07391102.2020.1820379
Deftereos, Giannopoulos, Vrachatis, Effect of colchicine vs standard care on cardiac and inflammatory biomarkers and clinical outcomes in patients hospitalized with coronavirus disease 2019; the GRECCO-19 randomized clinical trial, JAMA Netw Open, doi:10.1001/jamanetworkopen.2020.13136
Della-Torre, Della-Torre, Kusanovic, Scotti, Ramirez et al., Treating COVID-19 with colchicine in community healthcare setting, Clin Immunol, doi:10.1016/j.clim.2020.108490
Diaz, Orlandini, Castellana, Effect of colchicine vs usual care alone on intubation and 28-day mortality in patients hospitalized with COVID-19: a randomized clinical trial, JAMA Netw Open, doi:10.1001/jamanetworkopen.2021.41328
Imazio, Brucato, Lazaros, Anti-inflammatory therapies for pericardial diseases in the COVID-19 pandemic: safety and potentiality, J Cardiovasc Med, doi:10.2459/JCM.0000000000001059
Karatza, Ismailos, Karalis, Colchicine for the treatment of COVID-19 patients: efficacy, safety, and model informed dosage regimens, Xenobiotica, doi:10.1080/00498254.2021.1909782
Kow, Lee, Ramachandram, Hasan, Ming et al., The effect of colchicine on mortality outcome and duration of hospital stay in patients with COVID-19: a meta-analysis of randomized trials, Immun Inflamm Dis, doi:10.1002/iid3.562
Leung, Hui, Kraus, Colchicine--Update on mechanisms of action and therapeutic uses, Semin Arthritis Rheum, doi:10.1016/j.semarthrit.2015.06.013
Lin, Lu, Cao, Li, Hypothesis for potential pathogenesis of SARS-CoV-2 infection-a review of immune changes in patients with viral pneumonia, Emerg Microbes Infect, doi:10.1080/22221751.2020.1746199
Lopes, Bonjorno, Giannini, Beneficial effects of colchicine for moderate to severe COVID-19: a randomised, double-blinded, placebo-controlled clinical trial, RMD Open, doi:10.1136/rmdopen-2020-001455
Mehta, Mcauley, Brown, Sanchez, Tattersall et al., COVID-19: consider cytokine storm syndromes and immunosuppression, Lancet, doi:10.1016/S0140-6736(20)30628-0
Mikolajewska, Fischer, Piechotta, Colchicine for the treatment of COVID-19, Cochrane Database Syst Rev, doi:10.1002/14651858.CD015045
Salehzadeh, Pourfarzi, Ataei, The impact of colchicine on COVID-19 patients: a clinical trial study, Mediterr J Rheumatol, doi:10.31138/mjr.33.2.232
Sandhu, Tieng, Chilimuri, Franchin, A case control study to evaluate the impact of colchicine on patients admitted to the hospital with moderate to severe COVID-19 infection, Can J Infect Dis Med Microbiol, doi:10.1155/2020/8865954
Scarsi, Piantoni, Colombo, Association between treatment with colchicine and improved survival in a single-centre cohort of adult hospitalised patients with COVID-19 pneumonia and acute respiratory distress syndrome, Ann Rheum Dis, doi:10.1136/annrheumdis-2020-217712
Shah, Kumar, Patel, Myocarditis and pericarditis in patients with COVID-19, Heart Views, doi:10.4103/HEARTVIEWS.HEARTVIEWS_154_20
Tardif, Kouz, Waters, Efficacy and safety of low-dose colchicine after myocardial infarction, N Engl J Med, doi:10.1056/NEJMoa1912388
Toljan, Vrooman, Low-dose naltrexone (LDN)-review of therapeutic utilization, Med Sci, doi:10.3390/medsci6040082
Vitiello, Ferrara, Colchicine and SARS-CoV-2: management of the hyperinflammatory state, Respir Med, doi:10.1016/j.rmed.2021.106322
Vrachatis, Papathanasiou, Giotaki, Immunologic dysregulation and hypercoagulability as a pathophysiologic background in COVID-19 infection and the immunomodulating role of colchicine, J Clin Med, doi:10.3390/jcm10215128
Welzel, Wildermuth, Deschner, Benseler, Kuemmerle-Deschner, Colchicine -an effective treatment for children with a clinical diagnosis of autoinflammatory diseases without pathogenic gene variants, Pediatr Rheumatol Online J, doi:10.1186/s12969-021-00588-0
Wu, Chen, Cai, Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China, JAMA Intern Med, doi:10.1001/jamainternmed.2020.0994
{ 'indexed': {'date-parts': [[2024, 5, 16]], 'date-time': '2024-05-16T00:36:43Z', 'timestamp': 1715819803289}, 'reference-count': 26, 'publisher': 'Springer Science and Business Media LLC', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2024, 5, 15]]}, 'DOI': '10.7759/cureus.60364', 'type': 'journal-article', 'created': {'date-parts': [[2024, 5, 15]], 'date-time': '2024-05-15T19:31:40Z', 'timestamp': 1715801500000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Colchicine and/or Naltrexone for Hospitalized COVID-19 Patients Not Requiring High Levels of ' 'Ventilatory Support (COLTREXONE): A Prospective, Randomized, Open-Label Trial', 'prefix': '10.7759', 'author': [ {'given': 'Elie', 'family': 'Gertner', 'sequence': 'first', 'affiliation': []}, {'given': 'Anne', 'family': 'Schullo-Feulner', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alison', 'family': 'Knutson', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ella', 'family': 'Chrenka', 'sequence': 'additional', 'affiliation': []}, {'given': 'Meghan', 'family': "O'Brien", 'sequence': 'additional', 'affiliation': []}, {'given': 'Christine', 'family': 'Behrendt', 'sequence': 'additional', 'affiliation': []}, {'given': 'Joseph', 'family': 'Johnson', 'sequence': 'additional', 'affiliation': []}, {'given': 'Daniel', 'family': 'Delaney', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'reference': [ { 'key': 'ref1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0140-6736(20)30628-0', 'article-title': 'COVID-19: consider cytokine storm syndromes and immunosuppression', 'volume': '395', 'author': 'Mehta P', 'year': '2020', 'unstructured': 'Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ. ' 'COVID-19: consider cytokine storm syndromes and immunosuppression. ' 'Lancet. 2020, 395:1033-4. 10.1016/S0140-6736(20)30628-0', 'journal-title': 'Lancet'}, { 'key': 'ref2', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/22221751.2020.1746199', 'article-title': 'Hypothesis for potential pathogenesis of SARS-CoV-2 infection-a review ' 'of immune changes in patients with viral pneumonia', 'volume': '9', 'author': 'Lin L', 'year': '2020', 'unstructured': 'Lin L, Lu L, Cao W, Li T. Hypothesis for potential pathogenesis of ' 'SARS-CoV-2 infection-a review of immune changes in patients with viral ' 'pneumonia. Emerg Microbes Infect. 2020, 9:727-32. ' '10.1080/22221751.2020.1746199', 'journal-title': 'Emerg Microbes Infect'}, { 'key': 'ref3', 'doi-asserted-by': 'publisher', 'DOI': '10.1001/jamainternmed.2020.0994', 'article-title': 'Risk factors associated with acute respiratory distress syndrome and ' 'death in patients with coronavirus disease 2019 pneumonia in Wuhan, ' 'China', 'volume': '180', 'author': 'Wu C', 'year': '2020', 'unstructured': 'Wu C, Chen X, Cai Y, et al.. Risk factors associated with acute ' 'respiratory distress syndrome and death in patients with coronavirus ' 'disease 2019 pneumonia in Wuhan, China. JAMA Intern Med. 2020, ' '180:934-43. 10.1001/jamainternmed.2020.0994', 'journal-title': 'JAMA Intern Med'}, { 'key': 'ref4', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.jacc.2020.04.031', 'article-title': 'COVID-19 and thrombotic or thromboembolic disease: implications for ' 'prevention, antithrombotic therapy, and follow-up: JACC ' 'state-of-the-art review', 'volume': '75', 'author': 'Bikdeli B', 'year': '2020', 'unstructured': 'Bikdeli B, Madhavan MV, Jimenez D, et al.. COVID-19 and thrombotic or ' 'thromboembolic disease: implications for prevention, antithrombotic ' 'therapy, and follow-up: JACC state-of-the-art review. J Am Coll Cardiol. ' '2020, 75:2950-73. 10.1016/j.jacc.2020.04.031', 'journal-title': 'J Am Coll Cardiol'}, { 'key': 'ref5', 'doi-asserted-by': 'publisher', 'DOI': '10.4103/HEARTVIEWS.HEARTVIEWS_154_20', 'article-title': 'Myocarditis and pericarditis in patients with COVID-19', 'volume': '21', 'author': 'Shah JZ', 'year': '2020', 'unstructured': 'Shah JZ, Kumar SA, Patel AA. Myocarditis and pericarditis in patients ' 'with COVID-19. Heart Views. 2020, 21:209-14. ' '10.4103/HEARTVIEWS.HEARTVIEWS_154_20', 'journal-title': 'Heart Views'}, { 'key': 'ref6', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.semarthrit.2015.06.013', 'article-title': 'Colchicine--Update on mechanisms of action and therapeutic uses', 'volume': '45', 'author': 'Leung YY', 'year': '2015', 'unstructured': 'Leung YY, Yao Hui LL, Kraus VB. Colchicine--Update on mechanisms of ' 'action and therapeutic uses. Semin Arthritis Rheum. 2015, 45:341-50. ' '10.1016/j.semarthrit.2015.06.013', 'journal-title': 'Semin Arthritis Rheum'}, { 'key': 'ref7', 'doi-asserted-by': 'publisher', 'DOI': '10.1056/NEJMoa1912388', 'article-title': 'Efficacy and safety of low-dose colchicine after myocardial infarction', 'volume': '381', 'author': 'Tardif JC', 'year': '2019', 'unstructured': 'Tardif JC, Kouz S, Waters DD, et al.. Efficacy and safety of low-dose ' 'colchicine after myocardial infarction. N Engl J Med. 2019, ' '381:2497-505. 10.1056/NEJMoa1912388', 'journal-title': 'N Engl J Med'}, { 'key': 'ref8', 'doi-asserted-by': 'publisher', 'DOI': '10.2459/JCM.0000000000001059', 'article-title': 'Anti-inflammatory therapies for pericardial diseases in the COVID-19 ' 'pandemic: safety and potentiality', 'volume': '21', 'author': 'Imazio M', 'year': '2020', 'unstructured': 'Imazio M, Brucato A, Lazaros G, et al.. Anti-inflammatory therapies for ' 'pericardial diseases in the COVID-19 pandemic: safety and potentiality. ' 'J Cardiovasc Med (Hagerstown). 2020, 21:625-9. ' '10.2459/JCM.0000000000001059', 'journal-title': 'J Cardiovasc Med (Hagerstown)'}, { 'key': 'ref9', 'doi-asserted-by': 'publisher', 'DOI': '10.1186/s12969-021-00588-0', 'article-title': 'Colchicine - an effective treatment for children with a clinical ' 'diagnosis of autoinflammatory diseases without pathogenic gene variants', 'volume': '19', 'author': 'Welzel T', 'year': '2021', 'unstructured': 'Welzel T, Wildermuth AL, Deschner N, Benseler SM, Kuemmerle-Deschner JB. ' 'Colchicine - an effective treatment for children with a clinical ' 'diagnosis of autoinflammatory diseases without pathogenic gene variants. ' 'Pediatr Rheumatol Online J. 2021, 19:142. 10.1186/s12969-021-00588-0', 'journal-title': 'Pediatr Rheumatol Online J'}, { 'key': 'ref10', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.rmed.2021.106322', 'article-title': 'Colchicine and SARS-CoV-2: management of the hyperinflammatory state', 'volume': '178', 'author': 'Vitiello A', 'year': '2021', 'unstructured': 'Vitiello A, Ferrara F. Colchicine and SARS-CoV-2: management of the ' 'hyperinflammatory state. Respir Med. 2021, 178:106322. ' '10.1016/j.rmed.2021.106322', 'journal-title': 'Respir Med'}, { 'key': 'ref11', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/00498254.2021.1909782', 'article-title': 'Colchicine for the treatment of COVID-19 patients: efficacy, safety, ' 'and model informed dosage regimens', 'volume': '51', 'author': 'Karatza E', 'year': '2021', 'unstructured': 'Karatza E, Ismailos G, Karalis V. Colchicine for the treatment of ' 'COVID-19 patients: efficacy, safety, and model informed dosage regimens. ' 'Xenobiotica. 2021, 51:643-56. 10.1080/00498254.2021.1909782', 'journal-title': 'Xenobiotica'}, { 'key': 'ref12', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s00011-022-01540-y', 'article-title': 'Colchicine for COVID-19: targeting NLRP3 inflammasome to blunt ' 'hyperinflammation', 'volume': '71', 'author': 'Bonaventura A', 'year': '2022', 'unstructured': 'Bonaventura A, Vecchié A, Dagna L, Tangianu F, Abbate A, Dentali F. ' 'Colchicine for COVID-19: targeting NLRP3 inflammasome to blunt ' 'hyperinflammation. Inflamm Res. 2022, 71:293-307. ' '10.1007/s00011-022-01540-y', 'journal-title': 'Inflamm Res'}, { 'key': 'ref13', 'doi-asserted-by': 'publisher', 'DOI': '10.1378/chest.120.4.1301', 'article-title': 'Initial evidence of endothelial cell apoptosis as a mechanism of ' 'systemic capillary leak syndrome', 'volume': '120', 'author': 'Assaly R', 'year': '2001', 'unstructured': 'Assaly R, Olson D, Hammersley J, Fan PS, Liu J, Shapiro JI, Kahaleh MB. ' 'Initial evidence of endothelial cell apoptosis as a mechanism of ' 'systemic capillary leak syndrome. Chest. 2001, 120:1301-8. ' '10.1378/chest.120.4.1301', 'journal-title': 'Chest'}, { 'key': 'ref14', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/jcm10215128', 'article-title': 'Immunologic dysregulation and hypercoagulability as a pathophysiologic ' 'background in COVID-19 infection and the immunomodulating role of ' 'colchicine', 'volume': '10', 'author': 'Vrachatis DA', 'year': '2021', 'unstructured': 'Vrachatis DA, Papathanasiou KA, Giotaki SG, et al.. Immunologic ' 'dysregulation and hypercoagulability as a pathophysiologic background in ' 'COVID-19 infection and the immunomodulating role of colchicine. J Clin ' 'Med. 2021, 10:5128. 10.3390/jcm10215128', 'journal-title': 'J Clin Med'}, { 'key': 'ref15', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.clim.2020.108490', 'article-title': 'Treating COVID-19 with colchicine in community healthcare setting', 'volume': '217', 'author': 'Della-Torre E', 'year': '2020', 'unstructured': 'Della-Torre E, Della-Torre F, Kusanovic M, Scotti R, Ramirez GA, Dagna ' 'L, Tresoldi M. Treating COVID-19 with colchicine in community healthcare ' 'setting. Clin Immunol. 2020, 217:108490. 10.1016/j.clim.2020.108490', 'journal-title': 'Clin Immunol'}, { 'key': 'ref16', 'doi-asserted-by': 'publisher', 'DOI': '10.1001/jamanetworkopen.2020.13136', 'article-title': 'Effect of colchicine vs standard care on cardiac and inflammatory ' 'biomarkers and clinical outcomes in patients hospitalized with ' 'coronavirus disease 2019; the GRECCO-19 randomized clinical trial', 'volume': '3', 'author': 'Deftereos SG', 'year': '2020', 'unstructured': 'Deftereos SG, Giannopoulos G, Vrachatis DA, et al.. Effect of colchicine ' 'vs standard care on cardiac and inflammatory biomarkers and clinical ' 'outcomes in patients hospitalized with coronavirus disease 2019; the ' 'GRECCO-19 randomized clinical trial. JAMA Netw Open. 2020, 3:e2013136. ' '10.1001/jamanetworkopen.2020.13136', 'journal-title': 'JAMA Netw Open'}, { 'key': 'ref17', 'doi-asserted-by': 'publisher', 'DOI': '10.1136/rmdopen-2020-001455', 'article-title': 'Beneficial effects of colchicine for moderate to severe COVID-19: a ' 'randomised, double-blinded, placebo-controlled clinical trial', 'volume': '7', 'author': 'Lopes MI', 'year': '2021', 'unstructured': 'Lopes MI, Bonjorno LP, Giannini MC, et al.. Beneficial effects of ' 'colchicine for moderate to severe COVID-19: a randomised, ' 'double-blinded, placebo-controlled clinical trial. RMD Open. 2021, ' '7:10.1136/rmdopen-2020-001455', 'journal-title': 'RMD Open'}, { 'key': 'ref18', 'doi-asserted-by': 'publisher', 'DOI': '10.1136/annrheumdis-2020-217712', 'article-title': 'Association between treatment with colchicine and improved survival in ' 'a single-centre cohort of adult hospitalised patients with COVID-19 ' 'pneumonia and acute respiratory distress syndrome', 'volume': '79', 'author': 'Scarsi M', 'year': '2020', 'unstructured': 'Scarsi M, Piantoni S, Colombo E, et al.. Association between treatment ' 'with colchicine and improved survival in a single-centre cohort of adult ' 'hospitalised patients with COVID-19 pneumonia and acute respiratory ' 'distress syndrome. Ann Rheum Dis. 2020, 79:1286-9. ' '10.1136/annrheumdis-2020-217712', 'journal-title': 'Ann Rheum Dis'}, { 'key': 'ref19', 'doi-asserted-by': 'publisher', 'DOI': '10.1155/2020/8865954', 'article-title': 'A case control study to evaluate the impact of colchicine on patients ' 'admitted to the hospital with moderate to severe COVID-19 infection', 'volume': '2020', 'author': 'Sandhu T', 'year': '2020', 'unstructured': 'Sandhu T, Tieng A, Chilimuri S, Franchin G. A case control study to ' 'evaluate the impact of colchicine on patients admitted to the hospital ' 'with moderate to severe COVID-19 infection. Can J Infect Dis Med ' 'Microbiol. 2020, 2020:8865954. 10.1155/2020/8865954', 'journal-title': 'Can J Infect Dis Med Microbiol'}, { 'key': 'ref20', 'doi-asserted-by': 'publisher', 'DOI': '10.31138/mjr.33.2.232', 'article-title': 'The impact of colchicine on COVID-19 patients: a clinical trial study', 'volume': '33', 'author': 'Salehzadeh F', 'year': '2022', 'unstructured': 'Salehzadeh F, Pourfarzi F, Ataei S. The impact of colchicine on COVID-19 ' 'patients: a clinical trial study. Mediterr J Rheumatol. 2022, 33:232-6. ' '10.31138/mjr.33.2.232', 'journal-title': 'Mediterr J Rheumatol'}, { 'key': 'ref21', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/medsci6040082', 'article-title': 'Low-dose naltrexone (LDN)-review of therapeutic utilization', 'volume': '6', 'author': 'Toljan K', 'year': '2018', 'unstructured': 'Toljan K, Vrooman B. Low-dose naltrexone (LDN)-review of therapeutic ' 'utilization. Med Sci (Basel). 2018, 6:82. 10.3390/medsci6040082', 'journal-title': 'Med Sci (Basel)'}, { 'key': 'ref22', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/07391102.2020.1820379', 'article-title': 'Naltrexone a potential therapeutic candidate for COVID-19', 'volume': '40', 'author': 'Choubey A', 'year': '2022', 'unstructured': 'Choubey A, Dehury B, Kumar S, Medhi B, Mondal P. Naltrexone a potential ' 'therapeutic candidate for COVID-19. J Biomol Struct Dyn. 2022, ' '40:963-70. 10.1080/07391102.2020.1820379', 'journal-title': 'J Biomol Struct Dyn'}, { 'key': 'ref23', 'doi-asserted-by': 'publisher', 'DOI': '10.1001/jamanetworkopen.2021.41328', 'article-title': 'Effect of colchicine vs usual care alone on intubation and 28-day ' 'mortality in patients hospitalized with COVID-19: a randomized clinical ' 'trial', 'volume': '4', 'author': 'Diaz R', 'year': '2021', 'unstructured': 'Diaz R, Orlandini A, Castellana N, et al.. Effect of colchicine vs usual ' 'care alone on intubation and 28-day mortality in patients hospitalized ' 'with COVID-19: a randomized clinical trial. JAMA Netw Open. 2021, ' '4:e2141328. 10.1001/jamanetworkopen.2021.41328', 'journal-title': 'JAMA Netw Open'}, { 'key': 'ref24', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S2213-2600(21)00435-5', 'article-title': 'Colchicine in patients admitted to hospital with COVID-19 (RECOVERY): a ' 'randomised, controlled, open-label, platform trial', 'volume': '9', 'year': '2021', 'unstructured': 'Colchicine in patients admitted to hospital with COVID-19 (RECOVERY). a ' 'randomised, controlled, open-label, platform trial. Lancet Respir Med. ' '2021, 9:1419-26. 10.1016/S2213-2600(21)00435-5', 'journal-title': 'Lancet Respir Med'}, { 'key': 'ref25', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/14651858.CD015045', 'article-title': 'Colchicine for the treatment of COVID-19', 'volume': '10', 'author': 'Mikolajewska A', 'year': '2021', 'unstructured': 'Mikolajewska A, Fischer AL, Piechotta V, et al.. Colchicine for the ' 'treatment of COVID-19. Cochrane Database Syst Rev. 2021, 10:CD015045. ' '10.1002/14651858.CD015045', 'journal-title': 'Cochrane Database Syst Rev'}, { 'key': 'ref26', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/iid3.562', 'article-title': 'The effect of colchicine on mortality outcome and duration of hospital ' 'stay in patients with COVID-19: a meta-analysis of randomized trials', 'volume': '10', 'author': 'Kow CS', 'year': '2022', 'unstructured': 'Kow CS, Lee LH, Ramachandram DS, Hasan SS, Ming LC, Goh HP. The effect ' 'of colchicine on mortality outcome and duration of hospital stay in ' 'patients with COVID-19: a meta-analysis of randomized trials. Immun ' 'Inflamm Dis. 2022, 10:255-64. 10.1002/iid3.562', 'journal-title': 'Immun Inflamm Dis'}], 'container-title': 'Cureus', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.cureus.com/articles/240800-colchicine-andor-naltrexone-for-hospitalized-covid-19-patients-not-requiring-high-levels-of-ventilatory-support-coltrexone-a-prospective-randomized-open-label-trial', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2024, 5, 15]], 'date-time': '2024-05-15T19:31:44Z', 'timestamp': 1715801504000}, 'score': 1, 'resource': { 'primary': { 'URL': 'https://www.cureus.com/articles/240800-colchicine-andor-naltrexone-for-hospitalized-covid-19-patients-not-requiring-high-levels-of-ventilatory-support-coltrexone-a-prospective-randomized-open-label-trial'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 5, 15]]}, 'references-count': 26, 'URL': 'http://dx.doi.org/10.7759/cureus.60364', 'relation': {}, 'ISSN': ['2168-8184'], 'subject': [], 'published': {'date-parts': [[2024, 5, 15]]}}
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit