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@CovidAnalysis
 

Colchicine Plus Phenolic Monoterpenes to Treat COVID-19

Mostafaie et al., NCT04392141, NCT04392141, Apr 2021
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https://c19early.org/mostafaie.html
Mortality 83% primary Improvement Relative Risk Hospitalization time 35% Colchicine  Mostafaie et al.  LATE TREATMENT  RCT Is late treatment with colchicine + phenolic monoterpenes beneficial for COVID-19? RCT 120 patients in Iran (April - November 2020) Shorter hospitalization with colchicine + phenolic monoterpenes (p=0.0001) c19early.org Mostafaie et al., NCT04392141, April 2021 Favorscolchicine Favorscontrol 0 0.5 1 1.5 2+
Colchicine for COVID-19
5th treatment shown to reduce risk in September 2020, now with p = 0.00000017 from 57 studies.
Lower risk for mortality, ICU, hospitalization, and recovery.
No treatment is 100% effective. Protocols combine treatments.
5,700+ studies for 161 treatments. c19early.org
RCT with 60 patients treated with colchicine and phenolic monoterpenes and 60 control patients in Iran, showing lower mortality with treatment. NCT04392141 (history).
Important missing comments or errors? Let us know.
risk of death, 83.3% lower, RR 0.17, p = 0.11, treatment 1 of 60 (1.7%), control 6 of 60 (10.0%), NNT 12, primary outcome.
hospitalization time, 34.7% lower, relative time 0.65, p < 0.001, treatment 59, control 54.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Mostafaie et al., 20 Apr 2021, Randomized Controlled Trial, Iran, preprint, 1 author, study period 1 April, 2020 - 1 November, 2020, dosage not specified, this trial uses multiple treatments in the treatment arm (combined with phenolic monoterpenes) - results of individual treatments may vary, trial NCT04392141 (history).
This PaperColchicineAll
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. IMA and WCH provide treatment protocols.
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