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0 0.5 1 1.5 2+ Mortality 83% primary Improvement Relative Risk Hospitalization time 35% c19early.org/o Mostafaie et al. NCT04392141 Colchicine RCT LATE Is late treatment with colchicine+phenolic monoterpenes beneficial for COVID-19? RCT 120 patients in Iran Shorter hospitalization with colchicine+phenolic monoterpenes (p=0.0001) Mostafaie et al., ClinicalTrials.gov, NCT04392141 Favors colchicine Favors control
Colchicine Plus Phenolic Monoterpenes to Treat COVID-19
Mostafaie et al., ClinicalTrials.gov, NCT04392141 (Preprint), NCT04392141 (history)
Mostafaie et al., Colchicine Plus Phenolic Monoterpenes to Treat COVID-19, ClinicalTrials.gov, NCT04392141 (Preprint), NCT04392141
Apr 2021   Source   PDF  
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RCT with 60 patients treated with colchicine and phenolic monoterpenes and 60 control patients in Iran, showing lower mortality with treatment. NCT04392141 (history).
risk of death, 83.3% lower, RR 0.17, p = 0.11, treatment 1 of 60 (1.7%), control 6 of 60 (10.0%), NNT 12, primary outcome.
hospitalization time, 34.7% lower, relative time 0.65, p < 0.001, treatment 59, control 54.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Mostafaie et al., 20 Apr 2021, Randomized Controlled Trial, Iran, preprint, 1 author, dosage not specified, this trial uses multiple treatments in the treatment arm (combined with phenolic monoterpenes) - results of individual treatments may vary, trial NCT04392141 (history).
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This PaperColchicineAll
Late treatment
is less effective
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