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All Studies   Meta Analysis    Recent:   

Colchicine Is Safe Though Ineffective in the Treatment of Severe COVID-19: a Randomized Clinical Trial (COLCHIVID)

Absalón-Aguilar et al., Journal of General Internal Medicine, doi:10.1007/s11606-021-07203-8
Nov 2021  
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Mortality 29% Improvement Relative Risk Progression to critical or.. 17% primary Recovery -13% Colchicine  Absalón-Aguilar et al.  LATE TREATMENT  DB RCT Is late treatment with colchicine beneficial for COVID-19? Double-blind RCT 116 patients in Mexico (May 2020 - April 2021) No significant difference in outcomes seen c19early.org Absalón-Aguilar et al., J. General Int.., Nov 2021 Favorscolchicine Favorscontrol 0 0.5 1 1.5 2+
Colchicine for COVID-19
5th treatment shown to reduce risk in September 2020
 
*, now with p = 0.00000031 from 56 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,800+ studies for 98 treatments. c19early.org
Very late stage RCT with 56 colchicine and 60 control patients in Mexico, showing no significant differences.
Although the 29% lower mortality is not statistically significant, it is consistent with the significant 28% lower mortality [17‑37%] from meta analysis of the 43 mortality results to date.
risk of death, 28.6% lower, RR 0.71, p = 0.74, treatment 4 of 56 (7.1%), control 6 of 60 (10.0%), NNT 35.
progression to critical or death, 17.0% lower, OR 0.83, p = 0.67, treatment 56, control 60, primary outcome, RR approximated with OR.
risk of no recovery, 13.0% higher, RR 1.13, p = 0.59, treatment 56, control 60, Kaplan–Meier.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Absalón-Aguilar et al., 9 Nov 2021, Double Blind Randomized Controlled Trial, placebo-controlled, Mexico, peer-reviewed, 18 authors, study period May 2020 - April 2021, dosage 1.5mg day 1, 1mg days 2-10.
This PaperColchicineAll
Colchicine Is Safe Though Ineffective in the Treatment of Severe COVID-19: a Randomized Clinical Trial (COLCHIVID)
MD Abdiel Absalón-Aguilar, MD Marina Rull-Gabayet, MD Alfredo Pérez-Fragoso, PhD Nancy R Mejía-Domínguez, PhD Carlos Núñez-Álvarez, MD, PhD David Kershenobich-Stalnikowitz, MD José Sifuentes-Osornio, MD Alfredo Ponce-De-León, MD, MSc Fernanda González-Lara, MD, MSc Eduardo Martín-Nares, MD Sharon Montesinos-Ramírez, MD Martha Ramírez-Alemón, MD Pamela Ramírez-Rangel, MD Manlio F Márquez, Juan Carlos Plata-Corona, Guillermo Juárez-Vega, MD, PhD Diana Gómez-Martín, MD, PhD Jiram Torres-Ruiz
Journal of General Internal Medicine, doi:10.1007/s11606-021-07203-8
BACKGROUND: Colchicine is an available, safe, and effective anti-inflammatory drug and has been suggested as a COVID-19 treatment, but its usefulness in hospitalized severe COVID-19 patients has not been thoroughly demonstrated. OBJECTIVE: To address the safety and efficacy of colchicine in hospitalized patients with severe COVID-19. DESIGN: We conducted a triple-blind parallel nonstratified placebo-controlled clinical trial. PARTICIPANTS: We recruited 116 hospitalized patients with severe COVID-19 in Mexico. INTERVENTIONS: Patients were randomized to receive 1.5 mg of colchicine or placebo at the time of the recruitment in the study (baseline) and 0.5 mg BID PO to complete 10 days of treatment. MAIN MEASURES: The primary composite outcome was the progression to critical disease or death. Besides, we evaluated immunological features at baseline and after recovery or disease progression in 20 patients. KEY RESULTS: Fifty-six patients were allocated to colchicine and 60 patients received placebo. The study was suspended after the second interim analysis demonstrated colchicine had no effect on the primary outcome (OR 0.83, 95%CI 0.35-1.93, P = 0.67), nor in the days of ICU and hospital stays. Adverse events were similar between groups (OR 1.63, 95% CI 0.66-3.88, P = 0.37). After colchicine treatment, patients had higher BUN and lower serum levels of IL-8, IL-12p70, and IL-17A.
Declarations Conflict of Interest The authors declare that they do not have a conflict of interest. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creat iveco mmons. org/ licen ses/ by/4. 0/. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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