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0 0.5 1 1.5 2+ Hospitalization 73% Improvement Relative Risk Improvement in dyspnea 38% Improvement in Ct score 22% Colchicine  Pourdowlat et al.  LATE TREATMENT  RCT Is late treatment with colchicine beneficial for COVID-19? RCT 202 patients in Iran (March - September 2020) Lower hospitalization (p=0.0037) and improved recovery (p=0.025) Pourdowlat et al., Phytotherapy Research, Feb 2022 Favors colchicine Favors control

Efficacy and safety of colchicine treatment in patients with COVID-19: A prospective, multicenter, randomized clinical trial

Pourdowlat et al., Phytotherapy Research, doi:10.1002/ptr.7319
Feb 2022  
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Colchicine for COVID-19
6th treatment shown to reduce risk in September 2020
*, now known with p = 0.00000056 from 50 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
RCT 202 patients in Iran, 102 treated with colchicine, showing lower hospitalization and improved clinical outcomes with treatment.
risk of hospitalization, 72.8% lower, RR 0.27, p = 0.004, treatment 5 of 102 (4.9%), control 18 of 100 (18.0%), NNT 7.6.
relative improvement in dyspnea, 37.5% better, RR 0.62, p = 0.03, treatment 89, control 63, excluding 5 treatment and 37 control patients that needed hospitalization/other interventions.
relative improvement in Ct score, 22.4% better, RR 0.78, p = 0.048, treatment 89, control 63, excluding 5 treatment and 37 control patients that needed hospitalization/other interventions.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Pourdowlat et al., 2 Feb 2022, Randomized Controlled Trial, Iran, peer-reviewed, 18 authors, study period 26 March, 2020 - 30 September, 2020.
This PaperColchicineAll
Efficacy and safety of colchicine treatment in patients with COVID ‐19: A prospective, multicenter, randomized clinical trial
Guitti Pourdowlat, Fatemeh Saghafi, Abolfazl Mozafari, Adeleh Sahebnasagh, Atefeh Abedini, Mohsen Nabi Meybodi, Ali Salehi Nezamabadi, Seyed Ruhollah Mousavinasab, Arda Kiani, Hanieh Raji, Nadia Soltani, Mehdi Gholmzadeh Baeis, Esmaeil Eidani, Abdolrahim Sadeghi Yakhdani, Fatemeh Movaseghi, Solomon Habtemariam, Zohreh Akhoundi Meybodi, Mohsen Gholinataj Jelodar
Phytotherapy Research, doi:10.1002/ptr.7319
Colchicine has shown clinical benefits in the management of COVID-19 via its antiinflammatory effect. However, the exact role of colchicine in COVID-19 patients is unknown. The current clinical trial was performed on 202 patients with moderate to severe COVID-19. Patients were randomly assigned in a 1:1 ratio to receive up to a 3-day course of 0.5 mg colchicine followed by a 12-day course of 1 mg colchicine in combination with standard care or a 15-day course of standard care. Among 202 randomized patients, 153 completed the study and received colchicine/standard care or
CONFLICT OF INTEREST The authors declare that they have no conflicts of interest regarding the publication of this paper. AUTHOR CONTRIBUTIONS Guitti
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Late treatment
is less effective
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