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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality -9% Improvement Relative Risk Death/hospitalization -2% primary Hospitalization -2% c19early.org/o Eikelboom et al. NCT04324463 ACT outpatient Colchicine RCT LATE Favors colchicine Favors control
Colchicine and aspirin in community patients with COVID-19 (ACT): an open-label, factorial, randomised, controlled trial
Eikelboom et al., The Lancet Respiratory Medicine, doi:10.1016/S2213-2600(22)00299-5, ACT outpatient, NCT04324463 (history)
10 Oct 2022    Source   PDF   Share   Tweet
Late (5.4 days) outpatient RCT showing no significant difference in outcomes with colchicine treatment. Authors include a meta analysis of 6 colchicine RCTs, however there were 19 RCTs as of the publication date [c19colchicine.com].
risk of death, 9.0% higher, HR 1.09, p = 0.84, treatment 12 of 1,939 (0.6%), control 11 of 1,942 (0.6%).
risk of death/hospitalization, 2.0% higher, HR 1.02, p = 0.93, treatment 66 of 1,939 (3.4%), control 65 of 1,942 (3.3%), primary outcome.
risk of hospitalization, 2.0% higher, HR 1.02, p = 0.92, treatment 62 of 1,939 (3.2%), control 61 of 1,942 (3.1%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Eikelboom et al., 10 Oct 2022, Randomized Controlled Trial, Canada, peer-reviewed, mean age 45.0, 31 authors, study period 27 August, 2020 - 10 February, 2022, average treatment delay 5.4 days, dosage 1.2mg days 1-3, 0.6mg days 4-28, trial NCT04324463 (history) (ACT outpatient).
Contact: eikelbj@mcmaster.ca.
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This PaperColchicineAll
Late treatment
is less effective
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