Effectiveness of colchicine among patients with COVID-19 infection: A randomized, open-labeled, clinical trial

Jalal et al., Indian Journal of Rheumatology, doi:10.4103/injr.injr_264_21, NCT04867226, May 2022
Hospitalization time 24% improvement lower risk ← → higher risk Colchicine  Jalal et al.  LATE TREATMENT RCT Is late treatment with colchicine beneficial for COVID-19? RCT 80 patients in Iraq (May - June 2021) Shorter hospitalization with colchicine (p=0.009) c19early.org Jalal et al., Indian J. Rheumatology, May 2022 0 0.5 1 1.5 2+ RR
Colchicine for COVID-19
5th treatment shown to reduce risk in September 2020, now with p = 0.00000015 from 57 studies.
Lower risk for mortality, ICU, hospitalization, and recovery.
No treatment is 100% effective. Protocols combine treatments.
6,200+ studies for 200+ treatments. c19early.org
Open label RCT of colchicine showing improved recovery with treatment. Only the abstract is currently available. Colchicine 0.5mg bid for 14 days.
This study is excluded in the after exclusion results of meta analysis: minimal details provided.
hospitalization time, 24.1% lower, relative time 0.76, p = 0.009, treatment 36, control 44.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Jalal et al., 5 May 2022, Randomized Controlled Trial, Iraq, peer-reviewed, 3 authors, study period 8 May, 2021 - 18 June, 2021, trial NCT04867226 (history).
$0 $500 $1,000+ Efficacy vs. cost for COVID-19 treatment protocols c19early.org November 2025 United Kingdom Russia USA Sudan Angola Colombia Kenya Mozambique Pakistan Argentina Vietnam Peru Philippines Spain Brazil Italy France Japan China Uzbekistan Nepal Ethiopia Iran Ghana Mexico South Korea Germany Bangladesh Saudi Arabia Algeria Morocco Yemen Poland India DR Congo Madagascar Thailand Uganda Venezuela Nigeria Egypt Bolivia Taiwan Zambia Fiji Bosnia-Herzegovina Ukraine Côte d'Ivoire Bulgaria Greece Slovakia Singapore Iceland New Zealand Czechia Mongolia Israel Trinidad and Tobago Hong Kong North Macedonia Belarus Qatar Panama Serbia CAR Iraq favored high-profit treatments.The average efficacy of treatments was very low.High-cost protocols reduce early treatment, andforgo complementary/synergistic benefits. More effective More expensive 75% 50% 25% ≤0%
$0 $500 $1,000+ Efficacy vs. cost for COVID-19treatment protocols worldwide c19early.org November 2025 United Kingdom Russia USA Sudan Angola Colombia Kenya Mozambique Pakistan Argentina Vietnam Peru Philippines Spain Brazil Italy France Japan China Uzbekistan Nepal Ethiopia Iran Ghana Mexico South Korea Germany Bangladesh Saudi Arabia Algeria Morocco Yemen Poland India DR Congo Madagascar Thailand Uganda Venezuela Nigeria Egypt Bolivia Taiwan Zambia Fiji Ukraine Côte d'Ivoire Eritrea Bulgaria Greece Slovakia Singapore New Zealand Malawi Czechia Mongolia Israel Trinidad and Tobago North Macedonia Belarus Qatar Panama Serbia Syria Iraq favored high-profit treatments.The average efficacy was very low.High-cost protocols reduce early treatment,and forgo complementary/synergistic benefits. More effective More expensive 75% 50% 25% ≤0%
DOI record: { "DOI": "10.4103/injr.injr_264_21", "ISSN": [ "0973-3698" ], "URL": "http://dx.doi.org/10.4103/injr.injr_264_21", "alternative-id": [ "344591" ], "author": [ { "affiliation": [], "family": "Jalal", "given": "AryanMohamadfatih", "sequence": "first" }, { "affiliation": [], "family": "Aref", "given": "SheelanFaroz", "sequence": "additional" }, { "affiliation": [], "family": "Albustany", "given": "DashtyAbbas", "sequence": "additional" } ], "container-title": "Indian Journal of Rheumatology", "container-title-short": "Indian J Rheumatol", "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2022, 5, 3 ] ], "date-time": "2022-05-03T03:21:24Z", "timestamp": 1651548084000 }, "deposited": { "date-parts": [ [ 2022, 5, 3 ] ], "date-time": "2022-05-03T03:22:20Z", "timestamp": 1651548140000 }, "indexed": { "date-parts": [ [ 2022, 5, 4 ] ], "date-time": "2022-05-04T13:15:53Z", "timestamp": 1651670153419 }, "is-referenced-by-count": 0, "issue": "0", "issued": { "date-parts": [ [ 2022 ] ] }, "journal-issue": { "issue": "0", "published-print": { "date-parts": [ [ 2022 ] ] } }, "language": "en", "member": "2581", "original-title": [], "page": "0", "prefix": "10.4103", "published": { "date-parts": [ [ 2022 ] ] }, "published-print": { "date-parts": [ [ 2022 ] ] }, "publisher": "Medknow", "reference-count": 20, "references-count": 20, "relation": {}, "resource": { "primary": { "URL": "http://www.indianjrheumatol.com/preprintarticle.asp?id=344591;type=0" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [ "Rheumatology" ], "subtitle": [], "title": "Effectiveness of colchicine among patients with COVID-19 infection: A randomized, open-labeled, clinical trial", "type": "journal-article", "volume": "0" }
Late treatment
is less effective
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