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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality, day 28 71% Improvement Relative Risk Progression, day 28 71% Mortality, day 14 61% Ventilation 51% Progression, day 14 56% primary c19early.org/o Rahman et al. NCT04527562 Colchicine RCT LATE TREATMENT Favors colchicine Favors control
Efficacy of colchicine in patients with moderate COVID-19: A double-blinded, randomized, placebo-controlled trial
16 Nov 2022    Source   PDF   Share   Tweet
RCT 300 patients in Bangladesh, published 2 years after completion, showing significantly lower mortality with treatment at 28 days (not significant at 14 days). 1.2mg colchicine on day 1 followed by 0.6mg for 13 days.
risk of death, 71.0% lower, HR 0.29, p = 0.04, treatment 4 of 146 (2.7%), control 13 of 146 (8.9%), NNT 16, Cox proportional hazards, day 28.
risk of progression, 71.0% lower, HR 0.29, p = 0.04, treatment 4 of 146 (2.7%), control 13 of 146 (8.9%), NNT 16, 2 point deterioration, Cox proportional hazards, day 28.
risk of death, 61.0% lower, HR 0.39, p = 0.26, treatment 2 of 146 (1.4%), control 5 of 146 (3.4%), NNT 49, Cox proportional hazards, day 14.
risk of mechanical ventilation, 51.0% lower, HR 0.49, p = 0.41, treatment 2 of 146 (1.4%), control 4 of 146 (2.7%), NNT 73, Cox proportional hazards, day 14.
risk of progression, 56.0% lower, HR 0.44, p = 0.17, treatment 4 of 146 (2.7%), control 9 of 146 (6.2%), NNT 29, 2 point deterioration, Cox proportional hazards, day 14, primary outcome.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Rahman et al., 16 Nov 2022, Double Blind Randomized Controlled Trial, placebo-controlled, Bangladesh, peer-reviewed, 14 authors, study period June 2020 - November 2020, dosage 1.2mg day 1, 0.6mg days 2-14, trial NCT04527562 (history).
Contact: ponkajdatta@yahoo.com.
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This PaperColchicineAll
Late treatment
is less effective
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