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0 0.5 1 1.5 2+ Mortality 23% Improvement Relative Risk ICU time 40% Colchicine  Valerio Pascua et al.  ICU PATIENTS Is very late treatment with colchicine + combined treatments beneficial for COVID-19? Retrospective 65 patients in multiple countries (Jun - Aug 2020) Shorter ICU admission with colchicine + combined treatments (p=0.03) Valerio Pascua et al., PLOS ONE, January 2021 Favors colchicine Favors control

A multi-mechanism approach reduces length of stay in the ICU for severe COVID-19 patients

Valerio Pascua et al., PLOS ONE, doi:10.1371/journal.pone.0245025
Jan 2021  
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Colchicine for COVID-19
6th treatment shown to reduce risk in September 2020
*, now known with p = 0.00000056 from 50 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Retrospective 65 ICU patients in the USA and Honduras, showing shorter ICU stay with combined treatment including colchicine, LMWH, tocilizumab, dexamethasone, and methylprednisolone.
risk of death, 22.8% lower, RR 0.77, p = 0.60, treatment 5 of 35 (14.3%), control 12 of 30 (40.0%), NNT 3.9, adjusted per study, odds ratio converted to relative risk, multivariable.
ICU time, 39.9% lower, relative time 0.60, p = 0.03, treatment 35, control 30, adjusted per study, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Valerio Pascua et al., 7 Jan 2021, retrospective, multiple countries, peer-reviewed, 19 authors, study period 10 June, 2020 - 6 August, 2020, average treatment delay 6.1 days, dosage 1.5mg day 1, 1mg days 2-5, varied by location, this trial uses multiple treatments in the treatment arm (combined with LMWH, tocilizumab, dexamethasone, methylprednisolone) - results of individual treatments may vary.
This PaperColchicineAll
A multi-mechanism approach reduces length of stay in the ICU for severe COVID-19 patients
Fernando Valerio Pascua, Oscar Diaz, Rina Medina, Brian Contreras, Jeff Mistroff, Daniel Espinosa, Anupamjeet Sekhon, Diego Paz Handal, Estela Pineda, Miguel Vargas Pineda, Hector Pineda, Maribel Diaz, Anita S Lewis, Heike Hesse, Miriams T Castro Lainez, Mark L Stevens, Miguel Sierra- Hoffman, Sidney C Ontai, Vincent Vanburen
PLOS ONE, doi:10.1371/journal.pone.0245025
Purpose COVID-19 pandemic has multifaceted presentations with rising evidence of immune-mediated mechanisms underplay. We sought to explore the outcomes of severe COVID-19 patients treated with a multi-mechanism approach (MMA) in addition to standard-of-care (SC) versus patients who only received SC treatment. Materials and methods Data were collected retrospectively for patients admitted to the intensive care unit (ICU). This observational cohort study was performed at five institutions, 3 in the United States and 2 in Honduras. Patients were stratified for MMA vs. SC treatment during ICU stay. MMA treatment consists of widely available medications started immediately upon hospitalization. These interventions target immunomodulation, anticoagulation, viral suppression, and oxygenation. Primary outcomes included in-hospital mortality and length of stay (LOS) for the index hospitalization and were measured using logistic regression.
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Late treatment
is less effective
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