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Peginterferon lambda for the treatment of patients admitted to hospital with COVID-19: a phase 2, placebo-controlled randomised trial

Kandel et al., Clinical Microbiology and Infection, doi:10.1016/j.cmi.2025.08.003, ILIAD Cohort B, NCT04354259, Aug 2025
https://c19early.org/kandel.html
7-point scale -32% Improvement Relative Risk Peg.. Lambda  ILIAD Cohort B  LATE TREATMENT  DB RCT Is late treatment with peginterferon lambda beneficial for COVID-19? Double-blind RCT 94 patients in multiple countries Worse 7-point scale results with peginterferon lambda (not stat. sig., p=0.49) c19early.org Kandel et al., Clinical Microbiology a.., Aug 2025 Favorspeg.. lambda Favorscontrol 0 0.5 1 1.5 2+
RCT 97 hospitalized COVID-19 patients showing no significant benefit with peginterferon lambda.
risk of 7-point scale, 31.6% higher, OR 1.32, p = 0.49, treatment 48, control 46, inverted to make OR<1 favor treatment, day 14, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Kandel et al., 14 Aug 2025, Double Blind Randomized Controlled Trial, placebo-controlled, multiple countries, peer-reviewed, 21 authors, trial NCT04354259 (history) (ILIAD Cohort B).
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 200,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. IMA and WCH provide treatment protocols.
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