Optimus announces Interim Clinical Results from Phase III Clinical Trials of Molnupiravir conducted in India
Press Release (News)
, Optimus announces Interim Clinical Results from Phase III Clinical Trials of Molnupiravir conducted in India, Press Release (News)
Interim report on CTRI/2021/06/033992, showing faster viral clearance. Event counts are approximate, the press release only provides percentages.Concerns have been raised that the mutagenic mechanism of action may create dangerous variants or cause cancer [Hadj Hassine, Swanstrom]. See [Fountain-Jones, Sanderson, twitter.com] for analysis of variants potentially created by molnupiravir.
1.
Fountain-Jones et al., medRxiv, doi:10.1101/2022.12.21.22283811,
Antiviral treatments lead to the rapid accrual of hundreds of SARS-CoV-2 mutations in immunocompromised patients,
https://www.medrxiv.org/content/10.1101/2022.12.21.22283811.
2.
Hadj Hassine et al., Viruses, doi:10.3390/v14040841,
Lethal Mutagenesis of RNA Viruses and Approved Drugs with Antiviral Mutagenic Activity,
https://www.mdpi.com/1999-4915/14/4/841.
3.
Sanderson et al., medRxiv, doi:10.1101/2023.01.26.23284998,
Identification of a molnupiravir-associated mutational signature in SARS-CoV-2 sequencing databases,
https://www.medrxiv.org/content/10.1101/2023.01.26.23284998.
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risk of no viral clearance, 58.0% lower, RR 0.42, p < 0.001, treatment 38 of 175 (21.7%), control 93 of 180 (51.7%), NNT 3.3, day 5.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Optimus et al., 21 Jul 2021, Randomized Controlled Trial, India, preprint, 1 author.
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