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0 0.5 1 1.5 2+ Viral clearance 58% Improvement Relative Risk c19early.org/m Optimus et al. Molnupiravir for COVID-19 RCT EARLY Is early treatment with molnupiravir beneficial for COVID-19? RCT 355 patients in India Improved viral clearance with molnupiravir (p<0.000001) Optimus Press Release Favors molnupiravir Favors control
Optimus announces Interim Clinical Results from Phase III Clinical Trials of Molnupiravir conducted in India
Optimus Press Release (News)
Optimus, Optimus announces Interim Clinical Results from Phase III Clinical Trials of Molnupiravir conducted in India, Press Release (News)
Jul 2021   Source   PDF  
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Interim report on CTRI/2021/06/033992, showing faster viral clearance. Event counts are approximate, the press release only provides percentages.
Concerns have been raised that the mutagenic mechanism of action may create dangerous variants or cause cancer [Hadj Hassine, Swanstrom]. See [Fountain-Jones, Sanderson, twitter.com] for analysis of variants potentially created by molnupiravir.
risk of no viral clearance, 58.0% lower, RR 0.42, p < 0.001, treatment 38 of 175 (21.7%), control 93 of 180 (51.7%), NNT 3.3, day 5.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Optimus et al., 21 Jul 2021, Randomized Controlled Trial, India, preprint, 1 author.
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