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Optimus announces Interim Clinical Results from Phase III Clinical Trials of Molnupiravir conducted in India

Optimus, Press Release
Jul 2021  
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Viral clearance 58% Improvement Relative Risk Molnupiravir  Optimus et al.  EARLY TREATMENT  RCT Is early treatment with molnupiravir beneficial for COVID-19? RCT 355 patients in India Improved viral clearance with molnupiravir (p<0.000001) c19early.org Optimus, Press Release, July 2021 Favorsmolnupiravir Favorscontrol 0 0.5 1 1.5 2+
Interim report on CTRI/2021/06/033992, showing faster viral clearance. Event counts are approximate, the press release only provides percentages.
Potential risks include the creation of dangerous variants, and mutagenicity, carcinogenicity, teratogenicity, and embryotoxicity1-10. Multiple analyses have identified variants potentially created by molnupiravir11-14.
risk of no viral clearance, 58.0% lower, RR 0.42, p < 0.001, treatment 38 of 175 (21.7%), control 93 of 180 (51.7%), NNT 3.3, day 5.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Optimus et al., 21 Jul 2021, Randomized Controlled Trial, India, preprint, 1 author.
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