Optimus announces Interim Clinical Results from Phase III Clinical Trials of Molnupiravir conducted in India

Optimus, Press Release, Oct 2021
Early treatmentRCT · 1,202 patients · India
Molnupiravir for COVID-19
Optimus Press Release · October 2021
Worse recovery and improved viral clearance
p = 0.027 (recovery) and p < 0.0001 (viral clearance)
RCT 1,202 patients showing improved viral clearance, but no significant differences in clinical outcomes. Only interim results were reported by the manufacturer, the final results are from1. Some results are provided only as percentages without confirming if data was available for all patients - we assume all patients had data available.
Potential risks of molnupiravir include the creation of dangerous variants, and mutagenicity, carcinogenicity, teratogenicity, and embryotoxicity2-16. Multiple analyses have identified variants potentially created by molnupiravir17-21. Studies show significantly increased risk of acute kidney injury22, cardiovascular toxocity23, and neurological symptoms22. Treatment may increase viral rebound24,25.
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risk of hospitalization, 75.2% lower, RR 0.25, p = 0.22, treatment 1 of 603 (0.2%), control 4 of 599 (0.7%), NNT 199, day 14.
no 2-point ordinal scale improvement, 15.5% higher, RR 1.15, p = 0.03, treatment 286 of 603 (47.4%), control 246 of 599 (41.1%), day 28.
no 2-point ordinal scale improvement, 14.9% higher, RR 1.15, p = 0.02, treatment 303 of 603 (50.2%), control 262 of 599 (43.7%), day 14.
no 2-point ordinal scale improvement, 8.7% lower, RR 0.91, p = 0.09, treatment 308 of 603 (51.1%), control 335 of 599 (55.9%), NNT 21, day 10.
no 2-point ordinal scale improvement, 4.0% lower, RR 0.96, p = 0.27, treatment 431 of 603 (71.5%), control 446 of 599 (74.5%), NNT 34, day 5.
no 1-point ordinal scale improvement, 27.7% higher, RR 1.28, p = 0.80, treatment 9 of 603 (1.5%), control 7 of 599 (1.2%), day 28.
no 1-point ordinal scale improvement, 32.4% higher, RR 1.32, p = 0.66, treatment 12 of 603 (2.0%), control 9 of 599 (1.5%), day 14.
no 1-point ordinal scale improvement, 87.8% lower, RR 0.12, p < 0.001, treatment 13 of 603 (2.2%), control 106 of 599 (17.7%), NNT 6.4, day 10.
no 1-point ordinal scale improvement, 46.1% lower, RR 0.54, p < 0.001, treatment 127 of 603 (21.1%), control 234 of 599 (39.1%), NNT 5.6, day 5.
risk of no viral clearance, 40.6% lower, RR 0.59, p < 0.001, treatment 174 of 603 (28.9%), control 291 of 599 (48.6%), NNT 5.1, mid-recovery, day 5.
risk of no viral clearance, 0.7% lower, RR 0.99, p = 1.00, treatment 7 of 603 (1.2%), control 7 of 599 (1.2%), NNT 12900, day 14.
risk of no viral clearance, 86.0% lower, RR 0.14, p < 0.001, treatment 13 of 603 (2.2%), control 92 of 599 (15.4%), NNT 7.6, day 10.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Optimus et al., 28 Oct 2021, Randomized Controlled Trial, India, preprint, 1 author, licensee.
$0 $500 $1,000+ Efficacy vs. cost for COVID-19 treatment protocols c19early.org October 2026 India Angola Colombia Kenya Mozambique Myanmar South Africa Peru Philippines USA Brazil France Italy Canada Pakistan Spain Vietnam Japan Nepal Iran Bangladesh Ethiopia Ghana Germany Mexico South Korea United Kingdom Saudi Arabia Algeria Morocco Poland Thailand Uganda Egypt Nigeria Taiwan Fiji Zambia Bosnia-Herzegovina Dominican Republic Bolivia Côte d'Ivoire Eritrea Togo Bulgaria Greece Slovakia Iceland New Zealand Trinidad and Tobago Mongolia Czechia Belarus Israel North Macedonia Hong Kong Qatar Panama Serbia Benin Burundi Cameroon CAR India favored low-cost treatments.The average efficacy of treatments was moderate.Low-cost treatments improve early treatment, andprovide complementary/synergistic benefits. More effective More expensive 75% 50% 25% ≤0%
$0 $500 $1,000+ Efficacy vs. cost for COVID-19treatment protocols worldwide c19early.org October 2026 India Angola Colombia Kenya Mozambique Myanmar South Africa Peru Philippines USA Brazil France Italy Canada Pakistan Spain Vietnam Japan Iran Bangladesh Ethiopia Ghana Germany Mexico South Korea United Kingdom Saudi Arabia Algeria Morocco Yemen Poland Thailand Uganda Egypt Nigeria Taiwan Fiji Zambia Dominican Rep. Bolivia Côte d'Ivoire Eritrea Togo Sri Lanka Bulgaria Greece Slovakia New Zealand Trinidad and Tobago Mongolia Czechia Belarus Israel North Macedonia Hong Kong Qatar Panama Serbia Benin Burundi CAR Syria India favored low-cost treatments.The average efficacy was moderate.Low-cost protocols improve early treatment,and add complementary/synergistic benefits. More effective More expensive 75% 50% 25% ≤0%
Please send us corrections, updates, or comments. c19early involves the extraction of 200,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. IMA and WCH provide treatment protocols.
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