Effectiveness of Sotrovimab and Molnupiravir in community settings in England across the Omicron BA.1 and BA.2 sublineages: emulated target trials using the OpenSAFELY platform
et al., medRxiv, doi:10.1101/2023.05.12.23289914 (Preprint)
, Effectiveness of Sotrovimab and Molnupiravir in community settings in England across the Omicron BA.1 and BA.2.., medRxiv, doi:10.1101/2023.05.12.23289914 (Preprint)
OpenSAFELY retrospective 75,048 outpatients in the UK, using the clone-censor-weight approach to address immortal time bias, showing no significant difference in combined mortality/hospitalization with molnupiravir treatment.Concerns have been raised that the mutagenic mechanism of action may create dangerous variants or cause cancer [Hadj Hassine, Swanstrom]. See [Fountain-Jones, Sanderson, twitter.com] for analysis of variants potentially created by molnupiravir.
1.
Fountain-Jones et al., medRxiv, doi:10.1101/2022.12.21.22283811,
Antiviral treatments lead to the rapid accrual of hundreds of SARS-CoV-2 mutations in immunocompromised patients,
https://www.medrxiv.org/content/10.1101/2022.12.21.22283811.
2.
Hadj Hassine et al., Viruses, doi:10.3390/v14040841,
Lethal Mutagenesis of RNA Viruses and Approved Drugs with Antiviral Mutagenic Activity,
https://www.mdpi.com/1999-4915/14/4/841.
3.
Sanderson et al., medRxiv, doi:10.1101/2023.01.26.23284998,
Identification of a molnupiravir-associated mutational signature in SARS-CoV-2 sequencing databases,
https://www.medrxiv.org/content/10.1101/2023.01.26.23284998.
This study includes molnupiravir and sotrovimab.
|
risk of death/hospitalization, 9.0% higher, HR 1.09, p = 0.28, treatment 3,072, control 65,568.
|
| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Tazare et al., 16 May 2023, retrospective, United Kingdom, preprint, 31 authors, study period 16 December, 2021 - 21 May, 2022.
Loading..
Please send us corrections, updates, or comments. Vaccines and
treatments are complementary. All practical, effective, and safe means should
be used based on risk/benefit analysis. No treatment, vaccine, or intervention
is 100% available and effective for all current and future variants. We do not
provide medical advice. Before taking any medication, consult a qualified
physician who can provide personalized advice and details of risks and
benefits based on your medical history and situation. FLCCC and WCH
provide treatment protocols.