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All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Death/hospitalization 16% Improvement Relative Risk c19early.org/v Tazare et al. Sotrovimab for COVID-19 EARLY TREATMENT Is early treatment with sotrovimab beneficial for COVID-19? Retrospective 71,976 patients in the United Kingdom (Dec 2021 - May 2022) Lower death/hosp. with sotrovimab (p=0.0015) Tazare et al., medRxiv, doi:10.1101/2023.05.12.23289914 Favors sotrovimab Favors control

Effectiveness of Sotrovimab and Molnupiravir in community settings in England across the Omicron BA.1 and BA.2 sublineages: emulated target trials using the OpenSAFELY platform

Tazare et al., medRxiv, doi:10.1101/2023.05.12.23289914 (Preprint)
Tazare et al., Effectiveness of Sotrovimab and Molnupiravir in community settings in England across the Omicron BA.1 and BA.2.., medRxiv, doi:10.1101/2023.05.12.23289914 (Preprint)
May 2023   Source   PDF  
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OpenSAFELY retrospective 75,048 outpatients in the UK, using the clone-censor-weight approach to address immortal time bias, showing lower combined mortality/hospitalization with sotrovimab treatment.
Efficacy is variant dependent. In Vitro studies predict lower efficacy for BA.1 [Liu, Sheward, VanBlargan] and a lack of efficacy for BA.2 [Zhou]. US EUA has been revoked.
This study includes molnupiravir and sotrovimab.
risk of death/hospitalization, 16.0% lower, HR 0.84, p = 0.002, treatment 6,408, control 65,568.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Tazare et al., 16 May 2023, retrospective, United Kingdom, preprint, 31 authors, study period 16 December, 2021 - 21 May, 2022.
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