Effectiveness of Sotrovimab and Molnupiravir in community settings in England across the Omicron BA.1 and BA.2 sublineages: emulated target trials using the OpenSAFELY platform
John Tazare, Linda Nab, Bang Zheng, William J Hulme, Amelia C A Green, Helen J Curtis, Viyaasan Mahalingasivam, Rose Higgins, Anna Schultze, Krishnan Bhaskaran, Amir Mehrkar, Andrea Schaffer, Rebecca M Smith, Christopher Bates, Jonathan Cockburn, John Parry, Frank Hester, Sam Harper, Rosalind M Eggo, Alex J Walker, Michael Marks, Mike Brown, Camille Maringe, Clémence Leyrat, Stephen J W Evans, Ben Goldacre, Brian Mackenna, Jonathan A C Sterne, Laurie A Tomlinson, Ian J Douglas
doi:10.1101/2023.05.12.23289914
Background The effectiveness of COVID-19 monoclonal antibody and antiviral therapies against severe COVID-19 outcomes is unclear. Initial benefit was shown in unvaccinated patients and before the Omicron variant emerged. We used the OpenSAFELY platform to emulate target trials to estimate the effectiveness of sotrovimab or molnupiravir, versus no treatment.
Methods With the approval of NHS England, we derived population-based cohorts of non-hospitalised high-risk individuals in England testing positive for SARS-CoV-2 during periods of dominance of the BA.1 (16/12/2021-10/02/2022) and BA.2 (11/02/2022-21/05/2022) Omicron sublineages. We used the clone-censor-weight approach to estimate the effect of treatment with sotrovimab or molnupiravir initiated within 5 days after positive test versus no treatment. Hazard ratios (HR) for COVID-19 hospitalisation or death within 28 days were estimated using weighted Cox models.
Results
Of the 35,856 [BA.1 period] and 39,192 [BA.2 period] patients, 1,830 [BA.1] and 1,242 [BA.2] were treated with molnupiravir and 2,244 [BA.1] and 4,164 [BA.2] with sotrovimab. The estimated HRs for molnupiravir versus untreated were 1.00 (95%CI: 0.81;1.22) [BA.1] and 1.22 (0.96;1.56) [BA.2]; corresponding HRs for sotrovimab versus untreated were 0.76 (0.66;0.89) [BA.1] and 0.92 (0.79;1.06) [BA.2].
Interpretation Compared with no treatment, sotrovimab was associated with reduced risk of adverse outcomes after COVID-19 in the BA.1 period, but there was weaker evidence of benefit in the BA2 period. Molnupiravir was not associated with reduced risk in either period.
Authors' contributors The study was conceptualised by LAT, IJD, JACS, JT, LN, BZ, SJWE, BG and BMK; data was curated by LN, JT, BZ, ACAG, HJC, RH, RMS, CB, JC, JP, FH and SH; and formally analysed by LN and JT; funding was acquired by BG; the investigation was done by LN and JT; to the methodology was contributed by JT, LN, JACS, LAT, IJD, BZ, WJH, AS, CM, C; project administration was done by JT, LN, AJW, BMK, LAT and IJD; resources were provided by AM, AJW, BG, BMK and LAT; software was developed by LN, JT, ACAG, HJC, RH and RMS; the project was supervised by IJD and LAT; the study was validated by JT, LN, BZ, WJH, ACAG, HJC and RH; the results were visualised by JT and LN; the original draft was written by JT, LN and LAT; all authors were involved in draft revisions and approving the final draft for submission; all authors had full access to the OpenSAFELY platform and accept responsibility for the decision to submit for publication. The corresponding author attests that all listed authors meet authorship criteria and that no others meeting the criteria have been omitted. Bennett Institute for Applied Data Science developers and principal investigators (WJH, RMS, AJW and BG) holding contracts with NHS England have access to the OpenSAFELY pseudonymised data tables as needed to develop the OpenSAFELY tools; these tools in turn enable researchers with OpenSAFELY Data Access Agreements to write and execute code for data management and data analysis (LN and JT) without direct..
References
Aggarwal, Beaty, Bennett, Change in effectiveness of sotrovimab for preventing hospitalization and mortality for at-risk COVID-19 outpatients during an Omicron BA.1 and BA.1.1-predominant phase, Int J Infect Dis IJID Off Publ Int Soc Infect Dis,
doi:10.1016/j.ijid.2022.10.002Aggarwal, Beaty, Bennett, Real-World Evidence of the Neutralizing Monoclonal Antibody Sotrovimab for Preventing Hospitalization and Mortality in COVID-19 Outpatients, J Infect Dis,
doi:10.1093/infdis/jiac206Bajema, Berry, Streja, Effectiveness of COVID-19 treatment with nirmatrelvir-ritonavir or molnupiravir among U.S. Veterans: target trial emulation studies with one-month and six-month outcomes, MedRxiv Prepr Serv Health Sci. Published online December,
doi:10.1101/2022.12.05.22283134Bernal, Da Silva, Musungaie, Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients, N Engl J Med,
doi:10.1056/NEJMoa2116044Blake, Leyrat, Mansfield, Propensity scores using missingness pattern information: a practical guide, Stat Med,
doi:10.1002/sim.8503Borenstein, Hedges, Higgins, Hr, A basic introduction to fixed-effect and random-effects models for meta-analysis, Res Synth Methods,
doi:10.1002/jrsm.12Brown, Saund, Qureshi, Demographics and Outcomes of Initial Phase of COVID-19 Medicines Delivery Units Across 4 UK Centers During Peak B1.1.529 Omicron Epidemic: A Service Evaluation, Open Forum Infect Dis,
doi:10.1093/ofid/ofac527Butler, Hobbs, Gbinigie, Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial, The Lancet,
doi:10.1016/S0140-6736(22)02597-1Cheng, Reyes, Satram, Real-World Effectiveness of Sotrovimab for the Early Treatment of COVID-19 During SARS-CoV-2 Delta and Omicron Waves in the USA, Infect Dis Ther,
doi:10.1007/s40121-022-00755-0England, Coronavirus, Interim clinical commissioning policy: Treatments for non-hospitalised patients with COVID-19
Fda, FDA updates Sotrovimab emergency use authorization
Green, Curtis, Higgins, Trends, variation, and clinical characteristics of recipients of antiviral drugs and neutralising monoclonal antibodies for covid-19 in community settings: retrospective, descriptive cohort study of 23.4 million people in OpenSAFELY, BMJ Med,
doi:10.1136/bmjmed-2022-000276Gupta, Gonzalez-Rojas, Juarez, Early Treatment for Covid-19 with SARS-CoV-2 Neutralizing Antibody Sotrovimab, N Engl J Med,
doi:10.1056/NEJMoa2107934Hernán, How to estimate the effect of treatment duration on survival outcomes using observational data, BMJ,
doi:10.1136/bmj.k182Hernán, Robins, Using Big Data to Emulate a Target Trial When a Randomized Trial Is Not Available, Am J Epidemiol,
doi:10.1093/aje/kwv254Hernán, Sauer, Hernández-Díaz, Platt, Shrier, Specifying a target trial prevents immortal time bias and other self-inflicted injuries in observational analyses, J Clin Epidemiol,
doi:10.1016/j.jclinepi.2016.04.014Lund, Richardson, Stürmer, The active comparator, new user study design in pharmacoepidemiology: historical foundations and contemporary application, Curr Epidemiol Rep,
doi:10.1007/s40471-015-0053-5Maringe, Benitez Majano, Exarchakou, Assessing the benefit of major surgery for elderly lung cancer patients using observational data, Int J Epidemiol,
doi:10.1093/ije/dyaa057Nab, Parker, Andrews, Changes in COVID-19-related mortality across key demographic and clinical subgroups in England from 2020 to 2022: a retrospective cohort study using the OpenSAFELY platform, Lancet Public Health,
doi:10.1016/S2468-2667(23)00079-8Nice, NICE recommends 3 treatments for COVID-19 in final draft guidance
Piccicacco, Zeitler, Ing, Real-world effectiveness of early remdesivir and sotrovimab in the highest-risk COVID-19 outpatients during the Omicron surge, J Antimicrob Chemother,
doi:10.1093/jac/dkac256Schneeweiss, Avorn, A review of uses of health care utilization databases for epidemiologic research on therapeutics, J Clin Epidemiol,
doi:10.1016/j.jclinepi.2004.10.012Schneeweiss, Patrick, Stürmer, Increasing levels of restriction in pharmacoepidemiologic database studies of elderly and comparison with randomized trial results, Med Care,
doi:10.1097/MLR.0b013e318070c08eStürmer, Wang, Golightly, Keil, Lund et al., Methodological considerations when analysing and interpreting real-world data, Rheumatol Oxf Engl,
doi:10.1093/rheumatology/kez320Vanderweele, Unmeasured confounding and hazard scales: sensitivity analysis for total, direct, and indirect effects, Eur J Epidemiol,
doi:10.1007/s10654-013-9770-6Who, Therapeutics and COVID-19: Living guideline
Xie, Bowe, Al-Aly, Molnupiravir and risk of hospital admission or death in adults with covid-19: emulation of a randomized target trial using electronic health records, BMJ,
doi:10.1136/bmj-2022-072705Zaqout, Almaslamani, Chemaitelly, Effectiveness of the neutralizing antibody sotrovimab among high-risk patients with mild-to-moderate SARS-CoV-2 in Qatar, Int J Infect Dis IJID Off Publ Int Soc Infect Dis,
doi:10.1016/j.ijid.2022.09.023Zheng, Green, Tazare, Comparative effectiveness of sotrovimab and molnupiravir for prevention of severe covid-19 outcomes in patients in the community: observational cohort study with the OpenSAFELY platform, BMJ,
doi:10.1136/bmj-2022-071932DOI record:
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