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All Studies   All Outcomes   Recent:  
0 0.5 1 1.5 2+ Symp. case, MITT 24% Improvement Relative Risk Molnupiravir  MOVe-AHEAD  Prophylaxis  DB RCT Is prophylaxis with molnupiravir beneficial for COVID-19? Double-blind RCT 1,527 patients in multiple countries Fewer symptomatic cases with molnupiravir (not stat. sig., p=0.057) c19early.org Alpizar et al., J. Infection, September 2023 Favors molnupiravir Favors control

Molnupiravir for Intra-Household Prevention of COVID-19: the MOVe-AHEAD Randomized, Placebo-Controlled Trial

Alpizar et al., Journal of Infection, doi:10.1016/j.jinf.2023.08.016, MOVe-AHEAD, NCT04939428
Sep 2023  
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PEP RCT 1,527 patients showing lower COVID-19 cases with molnupiravir, without statistical significance.
Concerns have been raised that the mutagenic mechanism of action may create dangerous variants or cause cancer Hadj Hassine, Huntsman, Marikawa, Swanstrom, Waters, Zibat. Multiple analyses have identifed variants potentially created by molnupiravir Fountain-Jones, Sanderson, twitter.com.
risk of symptomatic case, 24.2% lower, RR 0.76, p = 0.06, treatment 78 of 763 (10.2%), control 103 of 764 (13.5%), NNT 31, MITT.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Alpizar et al., 8 Sep 2023, Double Blind Randomized Controlled Trial, placebo-controlled, multiple countries, peer-reviewed, 18 authors, trial NCT04939428 (history) (MOVe-AHEAD).
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