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@CovidAnalysis
All Studies   All Outcomes       

Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Dose Escalation and Proof-of-Concept Study to Evaluate the Safety and Efficacy of Razuprotafib in Hospitalized Subjects With Coronavirus Disease 2019

Paggiarino et al., NCT04511650, RESCUE, NCT04511650
Feb 2021  
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Mortality -5% Improvement Relative Risk Death or respiratory failure -178% Discharge -469% Razuprotafib  RESCUE  LATE TREATMENT  DB RCT Is late treatment with razuprotafib beneficial for COVID-19? Double-blind RCT 31 patients in the USA Higher progression (p=0.37) and lower discharge (p=0.28), not sig. c19early.org Paggiarino et al., NCT04511650, February 2021 Favorsrazuprotafib Favorscontrol 0 0.5 1 1.5 2+
RCT 29 patients showing no significant differences with razuprotafib treatment.
Important missing comments or errors? Let us know.
risk of death, 5.3% higher, RR 1.05, p = 1.00, treatment 2 of 19 (10.5%), control 1 of 10 (10.0%).
death or respiratory failure, 177.8% higher, RR 2.78, p = 0.37, treatment 5 of 18 (27.8%), control 1 of 10 (10.0%), day 28.
risk of no hospital discharge, 468.7% higher, RR 5.69, p = 0.28, treatment 3 of 16 (18.8%), control 0 of 9 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Paggiarino et al., 26 Feb 2021, Double Blind Randomized Controlled Trial, placebo-controlled, USA, preprint, 1 author, trial NCT04511650 (history) (RESCUE). Contact: dpaggiarino@eyepointpharma.com.
This PaperRazuprotafibAll
Late treatment
is less effective
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