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0 0.5 1 1.5 2+ Mortality 88% Improvement Relative Risk Progression 93% Progression (b) 92% primary c19early.org/cp Avendaño-Solà et al. NCT04345523 Conv. Plasma RCT LATE Is late treatment with convalescent plasma beneficial for COVID-19? RCT 81 patients in Spain Lower progression with convalescent plasma (p=0.013) Avendaño-Solà et al., medRxiv, doi:10.1101/2020.08.26.20182444 Favors conv. plasma Favors control
Convalescent Plasma for COVID-19: A multicenter, randomized clinical trial
Avendaño-Solà et al., medRxiv, doi:10.1101/2020.08.26.20182444, NCT04345523 (history)
Avendaño-Solà et al., Convalescent Plasma for COVID-19: A multicenter, randomized clinical trial, medRxiv, doi:10.1101/2020.08.26.20182444, NCT04345523
Sep 2020   Source   PDF  
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Early terminated RCT with 81 hospitalized patients, 38 treated with convalescent plasma, showing lower progression with treatment. NCT04345523 (history).
risk of death, 88.3% lower, RR 0.12, p = 0.12, treatment 0 of 38 (0.0%), control 4 of 43 (9.3%), NNT 11, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 29.
risk of progression, 93.0% lower, RR 0.07, p = 0.01, treatment 0 of 38 (0.0%), control 7 of 43 (16.3%), NNT 6.1, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 29, progression to categories 5-7.
risk of progression, 91.9% lower, RR 0.08, p = 0.03, treatment 0 of 38 (0.0%), control 6 of 43 (14.0%), NNT 7.2, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 15, progression to categories 5-7, primary outcome.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Avendaño-Solà et al., 29 Sep 2020, Randomized Controlled Trial, Spain, peer-reviewed, 36 authors, average treatment delay 8.0 days, trial NCT04345523 (history).
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This PaperConv. PlasmaAll
Abstract: medRxiv preprint doi: https://doi.org/10.1101/2020.08.26.20182444; this version posted September 29, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license . Original Article Convalescent Plasma for COVID-19: A multicenter, randomized clinical trial Authors: C Avendaño-Solà1, A Ramos-Martínez2, E Muñez-Rubio2, B Ruiz-Antorán1, R Malo de Molina3, F Torres4, A Fernández-Cruz2, A Callejas-Díaz2, J Calderón2, C Payares-Herrera1, I Salcedo1, I Romera5, J LoraTamayo6, M Mancheño-Losa6, ML Paciello7, C Villegas7, V Estrada8, I Saez-Serrano9, ML Porras-Leal10, MC Jarilla-Fernández11, JR Paño-Pardo12, JA Moreno-Chulilla13, I Arrieta-Aldea14, A Bosch15, M Belhassen-Garcia16, O López-Villar17, A Ramos-Garrido18, L Blanco19, ME Madrigal-Sánchez20, E Contreras21, E Muñiz-Díaz22, JM Domingo-Morera23, I Casas-Flecha24, M Pérez-Olmeda25, Javier GarciaPérez26, J Alcamí26, JL Bueno5 and RF Duarte 5 for the ConPlas-19 Study Group* *Complete list of the ConPlas-19 study group provided in the Supplementary Appendix Affiliations: 1. Clinical Pharmacology Department. Hospital Universitario Puerta de Hierro Majadahonda, Instituto de Investigación Sanitaria Hospital Puerta de Hierro-Segovia de Arana, Madrid, Spain. SCReN Clinical Trials Platform. 2. Infectious Diseases Unit, Department of Internal Medicine. Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain. 3. Respiratory Medicine Service. Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain. 4. Clinical Pharmacology Department, Hospital Clinic Barcelona, Barcelona, Spain. Biostatistics Unit, Faculty of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain 5. Department of Hematology. Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain 6. Department of Internal Medicine. Hospital Universitario 12 de Octubre. Instituto de Investigación "i+12" Hospital 12 de Octubre, Madrid,Spain. 7. Department of Hematology. Hospital Universitario 12 de Octubre,Madrid, Spain 8. Infectious Diseases Unit, Department of Internal Medicine.Hospital Universitario Clinico San Carlos, Madrid, Spain. 9. Hematology Service. Hospital Universitario Clinico San Carlos. Madrid, Spain. 10. Infectious Diseases Unit, Department of Internal Medicine, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain. 11. Hematology and Hemotherapy Service, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain. 12. Division of Infectious Diseases. Hospital Clínico Universitario Zaragoza-IIS Aragón, Spain NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice. 1 medRxiv preprint doi: https://doi.org/10.1101/2020.08.26.20182444; this version posted September 29, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license . 13. Servicio de Hematología Hospital Clínico Universitario Lozano Blesa, Zaragoza,Spain 14. Infectious Diseases Department, Hospital del Mar, Barcelona, Spain. 15. Blood Transfusion Service. Hospital del Mar. Consorci Mar Parc de Salut. Banc de Sang i Teixits. Barcelona. Spain 16. Internal Medicine..
Late treatment
is less effective
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