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Home   COVID-19 treatment studies for Convalescent Plasma  COVID-19 treatment studies for Conv. Plasma  C19 studies: Conv. Plasma  Conv. Plasma   Select treatmentSelect treatmentTreatmentsTreatments
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0 0.5 1 1.5 2+ Mortality -212% Improvement Relative Risk Mortality (b) -12% Ventilation -425% Progression, day 28 -425% primary Progression, day 14 -425% primary c19early.org/cp Hsue et al. NCT04421404 CAPRI Conv. Plasma RCT LATE Is late treatment with convalescent plasma beneficial for COVID-19? Double-blind RCT 34 patients in the USA Higher mortality (p=0.47) and ventilation (p=0.21), not stat. sig. Hsue et al., NCT04421404 Favors conv. plasma Favors control
Effects of COVID-19 Convalescent Plasma (CCP) on Coronavirus-associated Complications in Hospitalized Patients (CAPRI)
Hsue et al., NCT04421404 (Preprint), CAPRI, NCT04421404 (history)
Hsue et al., Effects of COVID-19 Convalescent Plasma (CCP) on Coronavirus-associated Complications in Hospitalized Patients.., NCT04421404 (Preprint), CAPRI, NCT04421404
Aug 2021   Source   PDF  
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RCT 34 hospitalized patients in the USA, showing no significant difference with convalescent plasma treatment.
risk of death, 212.5% higher, RR 3.12, p = 0.47, treatment 1 of 16 (6.2%), control 0 of 18 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), day 28.
risk of death, 12.5% higher, RR 1.12, p = 1.00, treatment 1 of 16 (6.2%), control 1 of 18 (5.6%), all cause, day 28.
risk of mechanical ventilation, 425.0% higher, RR 5.25, p = 0.21, treatment 2 of 16 (12.5%), control 0 of 18 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), day 28.
risk of progression, 425.0% higher, RR 5.25, p = 0.21, treatment 2 of 16 (12.5%), control 0 of 18 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), death or mechanical ventilation, day 28, primary outcome.
risk of progression, 425.0% higher, RR 5.25, p = 0.21, treatment 2 of 16 (12.5%), control 0 of 18 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), death or mechanical ventilation, day 14, primary outcome.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Hsue et al., 23 Aug 2021, Double Blind Randomized Controlled Trial, placebo-controlled, USA, preprint, 1 author, trial NCT04421404 (history) (CAPRI).
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This PaperConv. PlasmaAll
Late treatment
is less effective
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