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Effects of COVID-19 Convalescent Plasma (CCP) on Coronavirus-associated Complications in Hospitalized Patients (CAPRI)

Hsue et al., NCT04421404, CAPRI, NCT04421404
Aug 2021  
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Mortality -212% Improvement Relative Risk Mortality (b) -12% Ventilation -425% Progression, day 28 -425% primary Progression, day 14 -425% primary Conv. Plasma  CAPRI  LATE TREATMENT  DB RCT Is late treatment with convalescent plasma beneficial for COVID-19? Double-blind RCT 34 patients in the USA (June 2020 - April 2021) Higher mortality (p=0.47) and ventilation (p=0.21), not sig. c19early.org Hsue et al., NCT04421404, August 2021 Favorsconv. plasma Favorscontrol 0 0.5 1 1.5 2+
RCT 34 hospitalized patients in the USA, showing no significant difference with convalescent plasma treatment.
risk of death, 212.5% higher, RR 3.12, p = 0.47, treatment 1 of 16 (6.2%), control 0 of 18 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), day 28.
risk of death, 12.5% higher, RR 1.12, p = 1.00, treatment 1 of 16 (6.2%), control 1 of 18 (5.6%), all cause, day 28.
risk of mechanical ventilation, 425.0% higher, RR 5.25, p = 0.21, treatment 2 of 16 (12.5%), control 0 of 18 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), day 28.
risk of progression, 425.0% higher, RR 5.25, p = 0.21, treatment 2 of 16 (12.5%), control 0 of 18 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), death or mechanical ventilation, day 28, primary outcome.
risk of progression, 425.0% higher, RR 5.25, p = 0.21, treatment 2 of 16 (12.5%), control 0 of 18 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), death or mechanical ventilation, day 14, primary outcome.
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Hsue et al., 23 Aug 2021, Double Blind Randomized Controlled Trial, placebo-controlled, USA, preprint, 1 author, study period 9 June, 2020 - 30 April, 2021, trial NCT04421404 (history) (CAPRI).
This PaperConv. PlasmaAll
Late treatment
is less effective
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