Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All convalescent plasma..
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchConvalescent PlasmaConv. Plasma (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   All Outcomes       

Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults

Libster et al., NEJM, doi:10.1056/NEJMoa2033700, INFANT-COVID-19, NCT04479163
Jan 2021  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Mortality 50% Improvement Relative Risk Ventilation 50% ICU admission 67% Progression 48% Conv. Plasma  INFANT-COVID-19  EARLY TREATMENT  DB RCT Is early treatment with convalescent plasma beneficial for COVID-19? Double-blind RCT 160 patients in Argentina (June - October 2020) Lower progression with convalescent plasma (p=0.029) c19early.org Libster et al., NEJM, January 2021 Favorsconv. plasma Favorscontrol 0 0.5 1 1.5 2+
RCT 160 patients >=65 with symptom onset <72 hours, 80 treated with convalescent plasma, showing lower progression to severe disease with treatment.
risk of death, 50.0% lower, RR 0.50, p = 0.43, treatment 2 of 80 (2.5%), control 4 of 80 (5.0%), NNT 40.
risk of mechanical ventilation, 50.0% lower, RR 0.50, p = 0.43, treatment 2 of 80 (2.5%), control 4 of 80 (5.0%), NNT 40.
risk of ICU admission, 67.0% lower, RR 0.33, p = 0.17, treatment 2 of 80 (2.5%), control 6 of 80 (7.5%), NNT 20.
risk of progression, 48.0% lower, RR 0.52, p = 0.03, treatment 13 of 80 (16.2%), control 25 of 80 (31.2%), NNT 6.7.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Libster et al., 6 Jan 2021, Double Blind Randomized Controlled Trial, Argentina, peer-reviewed, 56 authors, study period 4 June, 2020 - 25 October, 2020, trial NCT04479163 (history) (INFANT-COVID-19).
This PaperConv. PlasmaAll
Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults
Romina Libster, Gonzalo Pérez Marc, Diego Wappner, Silvina Coviello, Alejandra Bianchi, Virginia Braem, Ignacio Esteban, Mauricio T Caballero, Cristian Wood, Mabel Berrueta, Aníbal Rondan, Gabriela Lescano, Pablo Cruz, Yvonne Ritou, Valeria Fernández Viña, Damián Álvarez Paggi, Sebastián Esperante, Adrián Ferreti, Gastón Ofman, Álvaro Ciganda, Rocío Rodriguez, Jorge Lantos, Ricardo Valentini, Nicolás Itcovici, Alejandra Hintze, M Laura Oyarvide, Candela Etchegaray, Alejandra Neira, Ivonne Name, Julieta Alfonso, Rocío López Castelo, Gisela Caruso, Sofía Rapelius, Fernando Alvez, Federico Etchenique, Federico Dimase, Darío Alvarez, Sofía S Aranda, Clara Sánchez Yanotti, Julián De Luca, Sofía Jares Baglivo, Sofía Laudanno, Florencia Nowogrodzki, Ramiro Larrea, María Silveyra, Gabriel Leberzstein, Alejandra Debonis, Juan Molinos, Miguel González, Eduardo Perez, Nicolás Kreplak, Susana Pastor Argüello, Luz Gibbons, Fernando Althabe, Eduardo Bergel, Fernando P Polack
New England Journal of Medicine, doi:10.1056/nejmoa2033700
which is the author's version after external peer review and before publication in the Journal, is available under a CC BY license at PMC7793608.
Appendix The authors' full names and academic degrees are as follows: Romina Libster, M.D., Gonzalo Pérez Marc, M.D., Diego Wappner, M.D., Silvina Coviello, M.S., Alejandra Bianchi, Virginia Braem, Ignacio Esteban, M.D., Mauricio T. Caballero, M.D., Cristian Wood, M.D., Mabel Berrueta, M.D., Aníbal Rondan, M.D., Gabriela Lescano, M.D., Pablo Cruz, M.D., Yvonne Ritou, M.D., Valeria Fernández Viña, M.D., Damián Álvarez Paggi, Ph.D., Sebastián Esperante, Ph.D., Adrián Ferreti, Gastón Ofman, M.D., Álvaro Ciganda, B.I.T., Rocío Rodriguez, Jorge Lantos, M.D., Ricardo Valentini, M.D., Nicolás Itcovici, M.D., Alejandra Hintze, M.D., M. Laura Oyarvide, M.D., Candela Etchegaray, M.D., Alejandra Neira, M.D., Ivonne Name, M.D., Julieta Alfonso, M.D., Rocío López Castelo, M.D., Gisela Caruso, M.D., Sofía Rapelius, M.S., Fernando Alvez, M.D., Federico Etchenique, M.D., Federico Dimase, M.D., Darío Alvarez, M.S., Sofía S. Aranda, M.D., Clara Sánchez Yanotti, Julián De Luca, Sofía Jares Baglivo, Sofía Laudanno, Florencia Nowogrodzki, Ramiro Larrea, M.
References
Agarwal, Mukherjee, Kumar, Chatterjee, Bhatnagar et al., Convalescent plasma in the management of moderate covid-19 in adults in India: open label phase II multicentre randomised controlled trial (PLACID Trial), BMJ
Arciuolo, Jablonski, Zucker, Rosen, Effectiveness of measles vaccination and immune globulin post-exposure prophylaxis in an outbreak setting -New York City, 2013, Clin Infect Dis
Avendaño-Sola, Ramos-Martinez, Munez-Rubio, Convalescent plasma for COVID-19: a multicenter, randomized clinical trial, doi:10.1101/2020.08.26.20182444v1
Cao, Wang, Wen, A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19, N Engl J Med
Chen, Nirula, Heller, SARS-CoV-2 neutralizing antibody LY-CoV555 in outpatients with Covid-19, doi:10.1056/NEJMoa2029849.19
Gold, Rossen, Ahmad, Race, ethnicity, and age trends in persons who died from COVID-19 -United States, May-August 2020, MMWR Morb Mortal Wkly Rep
Joyner, Senefeld, Klassen, Effect of convalescent plasma on mortality among hospitalized patients with COVID-19: initial three-month experience, doi:10.1101/2020.08.12.20169359v1
Joyner, Wright, Fairweather, Early safety indicators of COVID-19 convalescent plasma in 5000 patients, J Clin Invest
Li, Zhang, Hu, Effect of convalescent plasma therapy on time to clinical improvement in patients with severe and life-threatening COVID-19: a randomized clinical trial, JAMA
Liu, Lin, Baine, Convalescent plasma treatment of severe COVID-19: a propensity score-matched control study, Nat Med
Maiztegui, Fernandez, De Damilano, Efficacy of immune plasma in treatment of Argentine haemorrhagic fever and association between treatment and a late neurological syndrome, Lancet
Salazar, Christensen, Graviss, Treatment of coronavirus disease 2019 patients with convalescent plasma reveals a signal of significantly decreased mortality, Am J Pathol
Simonovich, Pratx, Scibona, A randomized trial of convalescent plasma in Covid-19 severe pneumonia, N Engl J Med
Stokes, Zambrano, Anderson, Coronavirus disease 2019 case surveillance -United States, January 22, MMWR Morb Mortal Wkly Rep
Stone, Frigault, Boyd, Efficacy of tocilizumab in patients hospitalized with Covid-19, N Engl J Med
The, Group, Effect of hydroxychloroquine in hospitalized patients with Covid-19, N Engl J Med
Williamson, Walker, Bhaskaran, Factors associated with COVID-19-related death using OpenSAFELY, Nature
{ 'indexed': {'date-parts': [[2024, 4, 9]], 'date-time': '2024-04-09T19:53:48Z', 'timestamp': 1712692428389}, 'reference-count': 15, 'publisher': 'Massachusetts Medical Society', 'issue': '7', 'license': [ { 'start': { 'date-parts': [[2021, 2, 18]], 'date-time': '2021-02-18T00:00:00Z', 'timestamp': 1613606400000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'http://www.nejmgroup.org/legal/terms-of-use.htm'}], 'funder': [ { 'DOI': '10.13039/100000865', 'name': 'Bill and Melinda Gates Foundation', 'doi-asserted-by': 'publisher'}, {'name': 'The Fundacion INFANT Pandemic Fund'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2021, 2, 18]]}, 'DOI': '10.1056/nejmoa2033700', 'type': 'journal-article', 'created': {'date-parts': [[2021, 1, 6]], 'date-time': '2021-01-06T22:01:50Z', 'timestamp': 1609970510000}, 'page': '610-618', 'source': 'Crossref', 'is-referenced-by-count': 681, 'title': 'Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults', 'prefix': '10.1056', 'volume': '384', 'author': [ { 'given': 'Romina', 'family': 'Libster', 'sequence': 'first', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Gonzalo', 'family': 'Pérez Marc', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Diego', 'family': 'Wappner', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Silvina', 'family': 'Coviello', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Alejandra', 'family': 'Bianchi', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Virginia', 'family': 'Braem', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Ignacio', 'family': 'Esteban', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Mauricio T.', 'family': 'Caballero', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Cristian', 'family': 'Wood', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Mabel', 'family': 'Berrueta', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Aníbal', 'family': 'Rondan', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Gabriela', 'family': 'Lescano', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Pablo', 'family': 'Cruz', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Yvonne', 'family': 'Ritou', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Valeria', 'family': 'Fernández Viña', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Damián', 'family': 'Álvarez Paggi', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Sebastián', 'family': 'Esperante', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Adrián', 'family': 'Ferreti', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Gastón', 'family': 'Ofman', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Álvaro', 'family': 'Ciganda', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Rocío', 'family': 'Rodriguez', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Jorge', 'family': 'Lantos', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Ricardo', 'family': 'Valentini', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Nicolás', 'family': 'Itcovici', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Alejandra', 'family': 'Hintze', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'M. Laura', 'family': 'Oyarvide', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Candela', 'family': 'Etchegaray', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Alejandra', 'family': 'Neira', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Ivonne', 'family': 'Name', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Julieta', 'family': 'Alfonso', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Rocío', 'family': 'López Castelo', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Gisela', 'family': 'Caruso', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Sofía', 'family': 'Rapelius', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Fernando', 'family': 'Alvez', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Federico', 'family': 'Etchenique', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Federico', 'family': 'Dimase', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Darío', 'family': 'Alvarez', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Sofía S.', 'family': 'Aranda', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Clara', 'family': 'Sánchez Yanotti', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Julián', 'family': 'De Luca', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Sofía', 'family': 'Jares Baglivo', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Sofía', 'family': 'Laudanno', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Florencia', 'family': 'Nowogrodzki', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Ramiro', 'family': 'Larrea', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'María', 'family': 'Silveyra', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Gabriel', 'family': 'Leberzstein', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Alejandra', 'family': 'Debonis', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Juan', 'family': 'Molinos', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Miguel', 'family': 'González', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Eduardo', 'family': 'Perez', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Nicolás', 'family': 'Kreplak', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Susana', 'family': 'Pastor Argüello', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Luz', 'family': 'Gibbons', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Fernando', 'family': 'Althabe', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Eduardo', 'family': 'Bergel', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}, { 'given': 'Fernando P.', 'family': 'Polack', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., ' 'C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., ' 'S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., ' 'A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., ' 'F.E., J.M.), National Scientific and Technical Research Council ' '(M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. ' 'Lescano), Centro Gallego (P.C.), Instituto de Efectividad ' 'Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital ' 'Simplemente...'}]}], 'member': '150', 'reference': [ {'key': 'r1', 'doi-asserted-by': 'publisher', 'DOI': '10.15585/mmwr.mm6924e2'}, {'key': 'r2', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41586-020-2521-4'}, {'key': 'r3', 'doi-asserted-by': 'publisher', 'DOI': '10.15585/mmwr.mm6942e1'}, {'key': 'r4', 'doi-asserted-by': 'publisher', 'DOI': '10.1056/NEJMoa2001282'}, {'key': 'r5', 'doi-asserted-by': 'publisher', 'DOI': '10.1056/NEJMoa2022926'}, {'key': 'r6', 'doi-asserted-by': 'publisher', 'DOI': '10.1056/NEJMoa2028836'}, {'key': 'r7', 'doi-asserted-by': 'publisher', 'DOI': '10.1001/jama.2020.10044'}, {'key': 'r8', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.ajpath.2020.08.001'}, {'key': 'r9', 'doi-asserted-by': 'publisher', 'DOI': '10.1136/bmj.m3939'}, { 'key': 'r10', 'doi-asserted-by': 'crossref', 'first-page': '619', 'DOI': '10.1056/NEJMoa2031304', 'volume': '384', 'author': 'Simonovich VA', 'year': '2021', 'journal-title': 'N Engl J Med'}, {'key': 'r13', 'doi-asserted-by': 'publisher', 'DOI': '10.1172/JCI140200'}, {'key': 'r14', 'doi-asserted-by': 'publisher', 'DOI': '10.1093/cid/cix639'}, {'key': 'r16', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0140-6736(79)92335-3'}, {'key': 'r18', 'doi-asserted-by': 'publisher', 'DOI': '10.1056/NEJMoa2029849'}, {'key': 'r20', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41591-020-1088-9'}], 'container-title': 'New England Journal of Medicine', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'http://www.nejm.org/doi/pdf/10.1056/NEJMoa2033700', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2021, 2, 17]], 'date-time': '2021-02-17T22:03:25Z', 'timestamp': 1613599405000}, 'score': 1, 'resource': {'primary': {'URL': 'http://www.nejm.org/doi/10.1056/NEJMoa2033700'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021, 2, 18]]}, 'references-count': 15, 'journal-issue': {'issue': '7', 'published-print': {'date-parts': [[2021, 2, 18]]}}, 'alternative-id': ['10.1056/NEJMoa2033700'], 'URL': 'http://dx.doi.org/10.1056/NEJMoa2033700', 'relation': {}, 'ISSN': ['0028-4793', '1533-4406'], 'subject': ['General Medicine'], 'container-title-short': 'N Engl J Med', 'published': {'date-parts': [[2021, 2, 18]]}}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit