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0 0.5 1 1.5 2+ Mortality 50% Improvement Relative Risk Ventilation 50% ICU admission 67% Progression 48% Conv. Plasma  INFANT-COVID-19  EARLY TREATMENT  DB RCT Is early treatment with convalescent plasma beneficial for COVID-19? Double-blind RCT 160 patients in Argentina (June - October 2020) Lower progression with convalescent plasma (p=0.029) Libster et al., NEJM, January 2021 Favors conv. plasma Favors control

Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults

Libster et al., NEJM, doi:10.1056/NEJMoa2033700, INFANT-COVID-19, NCT04479163
Jan 2021  
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RCT 160 patients >=65 with symptom onset <72 hours, 80 treated with convalescent plasma, showing lower progression to severe disease with treatment.
risk of death, 50.0% lower, RR 0.50, p = 0.43, treatment 2 of 80 (2.5%), control 4 of 80 (5.0%), NNT 40.
risk of mechanical ventilation, 50.0% lower, RR 0.50, p = 0.43, treatment 2 of 80 (2.5%), control 4 of 80 (5.0%), NNT 40.
risk of ICU admission, 67.0% lower, RR 0.33, p = 0.17, treatment 2 of 80 (2.5%), control 6 of 80 (7.5%), NNT 20.
risk of progression, 48.0% lower, RR 0.52, p = 0.03, treatment 13 of 80 (16.2%), control 25 of 80 (31.2%), NNT 6.7.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Libster et al., 6 Jan 2021, Double Blind Randomized Controlled Trial, Argentina, peer-reviewed, 56 authors, study period 4 June, 2020 - 25 October, 2020, trial NCT04479163 (history) (INFANT-COVID-19).
This PaperConv. PlasmaAll
Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults
Romina Libster, Gonzalo Pérez Marc, Diego Wappner, Silvina Coviello, Alejandra Bianchi, Virginia Braem, Ignacio Esteban, Mauricio T Caballero, Cristian Wood, Mabel Berrueta, Aníbal Rondan, Gabriela Lescano, Pablo Cruz, Yvonne Ritou, Valeria Fernández Viña, Damián Álvarez Paggi, Sebastián Esperante, Adrián Ferreti, Gastón Ofman, Álvaro Ciganda, Rocío Rodriguez, Jorge Lantos, Ricardo Valentini, Nicolás Itcovici, Alejandra Hintze, M Laura Oyarvide, Candela Etchegaray, Alejandra Neira, Ivonne Name, Julieta Alfonso, Rocío López Castelo, Gisela Caruso, Sofía Rapelius, Fernando Alvez, Federico Etchenique, Federico Dimase, Darío Alvarez, Sofía S Aranda, Clara Sánchez Yanotti, Julián De Luca, Sofía Jares Baglivo, Sofía Laudanno, Florencia Nowogrodzki, Ramiro Larrea, María Silveyra, Gabriel Leberzstein, Alejandra Debonis, Juan Molinos, Miguel González, Eduardo Perez, Nicolás Kreplak, Susana Pastor Argüello, Luz Gibbons, Fernando Althabe, Eduardo Bergel, Fernando P Polack
New England Journal of Medicine, doi:10.1056/nejmoa2033700
which is the author's version after external peer review and before publication in the Journal, is available under a CC BY license at PMC7793608.
Appendix The authors' full names and academic degrees are as follows: Romina Libster, M.D., Gonzalo Pérez Marc, M.D., Diego Wappner, M.D., Silvina Coviello, M.S., Alejandra Bianchi, Virginia Braem, Ignacio Esteban, M.D., Mauricio T. Caballero, M.D., Cristian Wood, M.D., Mabel Berrueta, M.D., Aníbal Rondan, M.D., Gabriela Lescano, M.D., Pablo Cruz, M.D., Yvonne Ritou, M.D., Valeria Fernández Viña, M.D., Damián Álvarez Paggi, Ph.D., Sebastián Esperante, Ph.D., Adrián Ferreti, Gastón Ofman, M.D., Álvaro Ciganda, B.I.T., Rocío Rodriguez, Jorge Lantos, M.D., Ricardo Valentini, M.D., Nicolás Itcovici, M.D., Alejandra Hintze, M.D., M. Laura Oyarvide, M.D., Candela Etchegaray, M.D., Alejandra Neira, M.D., Ivonne Name, M.D., Julieta Alfonso, M.D., Rocío López Castelo, M.D., Gisela Caruso, M.D., Sofía Rapelius, M.S., Fernando Alvez, M.D., Federico Etchenique, M.D., Federico Dimase, M.D., Darío Alvarez, M.S., Sofía S. Aranda, M.D., Clara Sánchez Yanotti, Julián De Luca, Sofía Jares Baglivo, Sofía Laudanno, Florencia Nowogrodzki, Ramiro Larrea, M.
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