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All Studies   All Outcomes    Recent:   
0 0.5 1 1.5 2+ Mortality -45% Improvement Relative Risk ICU admission -8% ARDS -250% Hospitalization time -10% Conv. Plasma  Jalili et al.  LATE TREATMENT  RCT Is late treatment with convalescent plasma beneficial for COVID-19? RCT 120 patients in Iran (May - July 2020) Higher mortality (p=0.38) and ARDS (p=0.16), not sig. c19early.org Jalili et al., Tanaffos 21:1, January 2022 Favors conv. plasma Favors control

Effect of Convalescent Plasma Therapy on Clinical Improvement of COVID-19 Patients: A Randomized Clinical Trial

Jalili et al., Tanaffos 21:1
Jan 2022  
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RCT 120 hospitalized patients in Iran, showing no significant differences with convalescent plasma treatment.
risk of death, 45.5% higher, RR 1.45, p = 0.38, treatment 16 of 60 (26.7%), control 11 of 60 (18.3%).
risk of ICU admission, 8.0% higher, RR 1.08, p = 0.85, treatment 27 of 60 (45.0%), control 25 of 60 (41.7%).
risk of ARDS, 250.0% higher, RR 3.50, p = 0.16, treatment 7 of 60 (11.7%), control 2 of 60 (3.3%).
hospitalization time, 9.9% higher, relative time 1.10, p = 0.39, treatment 60, control 60.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Jalili et al., 1 Jan 2022, Randomized Controlled Trial, Iran, peer-reviewed, 15 authors, study period May 2020 - July 2020.
This PaperConv. PlasmaAll
Effect of Convalescent Plasma Therapy on Clinical Improvement of COVID-19 Patients: A Randomized Clinical Trial
Ebrahim Jalili, Salman Khazaei, Afshin Mohammadi, Fariba Keramat, Seyed Hamid Hashemi, Saeid Bashirian, Toos Kiani, Azizi Farid, Jalilian, Samereh Ghelichkhani, Manoochehr Karami, Maryam Farrokhi, Rashid Heidarimoghadam, Tahereh Abbasi Garavand, Ebrahim Daneshyar, Mohammad Abbasi
Background: Due to the critical condition of COVID-19, it is necessary to evaluate the efficacy of administrating convalescent plasma to COVID-19 patients. Therefore, we decided to design a clinical trial to investigate the effect of convalescent plasma of patients recovered from COVID-19 on the treatment outcome of COVID-19-infected patients. Materials and Methods: In this parallel randomized controlled clinical trial, patients in the intervention group received standard treatment plus convalescent plasma of patients recovered from COVID-19. We allocated 60 patients to each treatment group through balanced block randomization. Then, COVID-19 outcomes, vital signs, and biochemical parameters were compared between the two treatment groups by the independent t test and ANCOVA. Results: The mean age (SD) of the patients in the intervention and standard treatment groups was 52.84 (15.77) and 55.15 (14.34) years, respectively. Although patients in the intervention group reported more hospitalization days (11.45±5.86 vs. 10.42±6.79), death rates (26.67% vs. 18.13%), ICU admission (45 vs. 41.67%), and ARDS (11.67% vs. 3.33%), these differences were not statistically significant (P>0.05). Moreover, the two groups were homogenous in vital signs and biochemical parameters before and after treatment (P>0.05). Conclusion: The present study indicated that convalescent plasma therapy has no significant effect on the survival, hospitalization, and ICU admission of COVID-19 patients.
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Late treatment
is less effective
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