Libster (DB RCT)50%0.50 · 0.09–2.65death2/804/80INFANT-COVID-19 Libster (DB RCT)50%0.50 · 0.09–2.65ventilation2/804/80INFANT-COVID-19 Libster (DB RCT)67%0.33 · 0.07–1.60ICU2/806/80INFANT-COVID-19 Libster (DB RCT)48%0.52 · 0.29–0.94progression13/8025/80INFANT-COVID-19 Balcells (RCT)−247%3.47 · 0.35–11.88death5/282/30 Balcells (RCT)−163%2.63 · 0.43–9.10ventilation5/282/30 Balcells (RCT)−23%1.23 · 0.56–1.89progression13/2812/30 Van Hise (RCT)−441%5.41 · 0.29–101hosp.3/490/23 Korley (RCT)−396%4.96 · 0.58–42.15death5/2501/248C3PO Korley (RCT)10%0.90 · 0.64–1.26hosp.51/25756/254C3PO Korley (RCT)6%0.94 · 0.72–1.22progression77/25781/254C3PO Alemany (DB RCT)80%0.20 · 0.01–4.14death0/1882/188CONV-ERT Alemany (DB RCT)−5%1.05 · 0.60–1.84hosp.22/18821/188CONV-ERT Alemany (DB RCT)−5%1.05 · 0.85–1.30no recov.188 (n)188 (n)CONV-ERT Alemany (DB RCT)−4%1.04 · 0.97–1.11viral load188 (n)188 (n)CONV-ERT Alemany (DB RCT)4%0.96 · 0.88–1.05viral load188 (n)188 (n)CONV-ERT Gharbharan (DB RCT)−1%1.01 · 0.06–16.04death1/2071/209CoV-Early Gharbharan (DB RCT)67%0.33 · 0.01–8.16ventilation0/2071/209CoV-Early Gharbharan (DB RCT)14%0.86 · 0.59–1.22progression207 (n)209 (n)CoV-Early Gharbharan (DB RCT)42%0.58 · 0.33–1.02progression123 (n)103 (n)CoV-Early Gharbharan (DB RCT)39%0.61 · 0.28–1.34hosp.10/20718/209CoV-Early Gharbharan (DB RCT)−50%1.50 · 0.40–5.64hosp. time207 (n)209 (n)CoV-Early Gharbharan (DB RCT)−1%1.01 · 0.88–1.16no recov.137/207137/209CoV-Early Gharbharan (DB RCT)−8%1.08 · 0.00–88003recov. time207 (n)209 (n)CoV-Early Hoffmann (RCT)51%0.49 · 0.05–5.27death1/592/58COVIC-19 Hoffmann (RCT)91%0.09 · 0.01–1.60death/hosp.0/595/58COVIC-19 Hoffmann (RCT)89%0.11 · 0.01–2.00death/hosp.0/594/58COVIC-19 Hoffmann (RCT)67%0.33 · 0.01–7.97ICU0/591/58COVIC-19 Li (RCT)35%0.65 · 0.27–1.39death8/5112/50 Li (RCT)15%0.85 · 0.53–1.18no improv.25/5229/51 Li (RCT)76%0.24 · 0.07–0.64viral+4/2615/23 Avendaño-Solà (RCT)88%0.12 · 0.01–2.11death0/384/43ConPlas-19 Avendaño-Solà (RCT)93%0.07 · 0.00–1.19progression0/387/43ConPlas-19 Avendaño-Solà (RCT)92%0.08 · 0.00–1.40progression0/386/43ConPlas-19 Agarwal (RCT)−7%1.07 · 0.73–1.58death34/23531/229PLACID Agarwal (RCT)−7%1.07 · 0.73–1.58progression44/23541/229PLACID Agarwal (RCT)1%0.99 · 0.54–1.81ventilation19/22719/224PLACID Agarwal (RCT)28%0.72 · 0.55–0.95viral+56/17376/169PLACID Bajpai (RCT)−323%4.23 · 0.43–41.60death3/141/15ILBS-COVID-02 Bajpai (RCT)−114%2.14 · 0.22–21.10death2/141/15ILBS-COVID-02 Bajpai (RCT)−221%3.21 · 0.38–27.40ventilation3/141/15ILBS-COVID-02 Bajpai (RCT)25%0.75 · 0.54–1.04hosp. time14 (n)15 (n)ILBS-COVID-02 Bajpai (RCT)33%0.67 · 0.41–1.10viral load14 (n)15 (n)ILBS-COVID-02 AlQahtani (RCT)50%0.50 · 0.05–5.08death1/202/20 AlQahtani (RCT)33%0.67 · 0.22–2.01ventilation4/206/20 AlQahtani (RCT)22%0.78 · 0.57–1.07hosp. time20 (n)20 (n) Simonovich (RCT)4%0.96 · 0.50–1.83death25/22812/105PlasmAr Simonovich (RCT)19%0.81 · 0.50–1.317-point status228 (n)105 (n)PlasmAr Ray (RCT)33%0.67 · 0.30–1.50death10/4014/40 Horby et al. (RCT)−1%1.01 · 0.94–1.08death1,622/5,7951,610/5,763RECOVERY Horby et al. (RCT)0%1.00 · 0.93–1.07death1,399/5,7951,408/5,763RECOVERY Horby et al. (RCT)−1%1.01 · 0.97–1.06no disch.1,963/5,7951,941/5,763RECOVERY Gonzalez−7%1.07 · 0.76–1.50death60/13026/60OT¹ Gonzalez−1%1.01 · 0.76–1.34death70/13032/60OT¹ Pouladza.. (SB RCT)40%0.60 · 0.16–2.29death3/305/30 Pouladza.. (SB RCT)−30%1.30 · 0.99–1.71hosp. time30 (n)30 (n) Bennett-.. (DB RCT)19%0.81 · 0.36–1.86death16/595/15 Bennett-.. (DB RCT)11%0.89 · 0.34–2.31death14/594/15 Bennett-.. (DB RCT)0%1.00 · 0.75–1.32no improv.47/5912/15 Elhadi (ICU)−16%1.16 · 0.88–1.54death16/23265/442ICU patients Teofili (RCT)−100%2.00 · 0.16–24.33death1/41/8LIFESAVER Gharbharan (RCT)4%0.96 · 0.25–2.41death6/4311/43ConCoVid-19 Gharbharan (RCT)12%0.88 · 0.49–1.60no disch.43 (n)43 (n)ConCoVid-19 Cho−4%1.04 · 0.64–1.62death402 (n)4,642 (n) Sekine (RCT)−38%1.38 · 0.73–2.63death18/8013/80PLACOVID Sekine (RCT)−100%2.00 · 0.72–5.59death10/805/80PLACOVID Sekine (RCT)−11%1.11 · 0.74–1.66no improv.31/8028/80PLACOVID Sekine (RCT)−67%1.67 · 0.01–470hosp. time80 (n)80 (n)PLACOVID Kirenga (RCT)−21%1.21 · 0.51–2.89death10/698/67COVIDIT Kirenga (RCT)9%0.91 · 0.38–2.16progression9/417/29COVIDIT Kirenga (RCT)−50%1.50 · 0.81–2.77viral time67 (n)67 (n)COVIDIT Hsue (DB RCT)−212%3.12 · 0.14–71.70death1/160/18CAPRI Hsue (DB RCT)−12%1.12 · 0.08–16.55death1/161/18CAPRI Hsue (DB RCT)−425%5.25 · 0.27–102ventilation2/160/18CAPRI Hsue (DB RCT)−425%5.25 · 0.27–102progression2/160/18CAPRI Hsue (DB RCT)−425%5.25 · 0.27–102progression2/160/18CAPRI Devos (RCT)1%0.99 · 0.52–1.88death320 (n)163 (n)DAWn-plasma Devos (RCT)−8%1.08 · 0.65–1.80ventilation320 (n)163 (n)DAWn-plasma Devos (RCT)0%1.00 · 0.74–1.34ICU320 (n)163 (n)DAWn-plasma Bégin (RCT)−13%1.13 · 0.88–1.45death156/62569/313CONCOR-1 Bégin (RCT)−12%1.12 · 0.86–1.46death141/61463/307CONCOR-1 Bégin (RCT)−16%1.16 · 0.94–1.43death/int.199/61486/307CONCOR-1 Körper (RCT)37%0.63 · 0.33–1.22death11/5317/52CAPSID Körper (RCT)14%0.86 · 0.34–2.20death7/538/52CAPSID Körper (RCT)16%0.84 · 0.62–1.14no recov.30/5335/52CAPSID Abayomi (DB RCT)−17%1.17 · 0.58–2.35death7/116/11LACCPT Menichetti (RCT)23%0.77 · 0.39–1.49death14/23119/240TSUNAMI Menichetti (RCT)−4%1.04 · 0.62–1.75ventilation25/23125/240TSUNAMI Menichetti (RCT)12%0.88 · 0.59–1.33progression59/23167/239TSUNAMI Holm (RCT)45%0.55 · 0.11–2.84death2/173/14COP20 Holm (RCT)69%0.31 · 0.01–7.09ventilation0/171/14COP20 Holm (RCT)19%0.81 · 0.25–2.64progression4/164/13COP20 Holm (RCT)−57%1.57 · 0.52–4.74oxygen time17 (n)14 (n)COP20 Holm (RCT)−62%1.62 · 0.76–3.46hosp. time17 (n)14 (n)COP20 Ortigoza (DB RCT)12%0.88 · 0.63–1.20death59/46271/462CONTAIN COVID-19 Ortigoza (DB RCT)1%0.99 · 0.66–1.47death35/46339/463CONTAIN COVID-19 Ortigoza (DB RCT)8%0.92 · 0.74–1.16WHO scale468 (n)473 (n)CONTAIN COVID-19 Ortigoza (DB RCT)6%0.94 · 0.75–1.18WHO scale468 (n)473 (n)CONTAIN COVID-19 Ortigoza (DB RCT)−2%1.02 · 0.77–1.37PASC141 (n)140 (n)CONTAIN COVID-19 Ortigoza (DB RCT)5%0.95 · 0.54–1.67PASC141 (n)140 (n)CONTAIN COVID-19 Ortigoza (DB RCT)−15%1.15 · 0.59–2.25PASC141 (n)140 (n)CONTAIN COVID-19 Ortigoza (DB RCT)18%0.82 · 0.44–1.51PASC141 (n)140 (n)CONTAIN COVID-19 Ortigoza (DB RCT)−18%1.18 · 0.71–1.95PASC141 (n)140 (n)CONTAIN COVID-19 Bar (RCT)81%0.19 · 0.04–0.84death40 (n)39 (n)PennCCP2 Bar (RCT)44%0.56 · 0.24–1.29no improv.40 (n)39 (n)PennCCP2 Bar (RCT)51%0.49 · 0.18–1.30ventilation5/4010/39PennCCP2 Sullivan (DB RCT)86%0.14 · 0.01–2.75death0/5923/589CSSC-004 Sullivan (DB RCT)25%0.75 · 0.17–3.32ICU3/5924/589CSSC-004 Sullivan (DB RCT)54%0.46 · 0.26–0.80hosp.17/59237/589CSSC-004 Jalili (RCT)−45%1.45 · 0.74–2.87death16/6011/60 Jalili (RCT)−8%1.08 · 0.72–1.63ICU27/6025/60 Jalili (RCT)−250%3.50 · 0.76–16.17ARDS7/602/60 Jalili (RCT)−10%1.10 · 0.89–1.36hosp. time60 (n)60 (n) Baldeón (DB RCT)12%0.88 · 0.37–2.11death7/6312/95 van den Berg (RCT)17%0.83 · 0.41–1.68death11/5213/51PROTECT-Patient van den Berg (RCT)67%0.33 · 0.04–3.04ventilation1/523/51PROTECT-Patient van den Berg (RCT)5%0.95 · 0.55–1.63no improv.16/4718/50PROTECT-Patient van den Berg (RCT)−3%1.03 · 0.62–1.71no disch.18/4619/50PROTECT-Patient Mesina−29%1.29 · 0.70–2.36death18/6514/65 Mesina−60%1.60 · 0.96–2.65hosp. time65 (n)65 (n) De Santis (RCT)13%0.87 · 0.48–1.56death11/3625/71 De Santis (RCT)12%0.88 · 0.42–1.82death8/3618/71 Bajpai (RCT)−14%1.14 · 0.76–1.69death42/20037/200COPLA-II Bajpai (RCT)−19%1.19 · 0.69–2.06death25/20021/200COPLA-II Bajpai (RCT)−12%1.12 · 0.67–1.88ventilation27/20024/200COPLA-II Bajpai (RCT)−2%1.02 · 0.90–1.15ICU200 (n)200 (n)COPLA-II Bajpai (RCT)0%1.00 · 0.91–1.09hosp. time200 (n)200 (n)COPLA-II Bajpai (RCT)6%0.94 · 0.71–1.24no recov.64/20068/200COPLA-II Bajpai (RCT)−1%1.01 · 0.98–1.05viral+200 (n)200 (n)COPLA-II Rojas (SB RCT)−220%3.20 · 0.64–16.00death46 (n)45 (n)CP-COVID-19 Rojas (SB RCT)38%0.62 · 0.40–0.97no disch.46 (n)45 (n)CP-COVID-19 Rojas (SB RCT)−25%1.25 · 0.36–4.33viral+46 (n)45 (n)CP-COVID-19 Rojas (SB RCT)−16%1.16 · 0.33–4.08viral+46 (n)45 (n)CP-COVID-19 Rojas (SB RCT)−51%1.51 · 0.33–6.98viral+46 (n)45 (n)CP-COVID-19 Rojas (SB RCT)−12%1.12 · 0.16–7.84viral+46 (n)45 (n)CP-COVID-19 Song (RCT)−52%1.52 · 0.70–3.27death22/877/42COOP-COVID-19-MCTI Lacombe (RCT)49%0.51 · 0.20–1.32death7/6012/60CORIPLASM Lacombe (RCT)64%0.36 · 0.14–0.97death4/2211/27CORIPLASM Lacombe (RCT)−68%1.68 · 0.74–3.35progression13/608/60CORIPLASM Lacombe (RCT)−4%1.04 · 0.61–1.78progression19/6020/60CORIPLASM Lacombe (RCT)−7%1.07 · 0.00–9700hosp. time60 (n)60 (n)CORIPLASM Thorlaci.. (DB RCT)−76%1.76 · 0.62–5.01death15/984/46CCAP-2 Thorlaci.. (DB RCT)−88%1.88 · 0.56–6.33death12/983/46CCAP-2 Thorlaci.. (DB RCT)−72%1.72 · 0.50–5.87death11/983/46CCAP-2 Thorlaci.. (DB RCT)−64%1.64 · 0.36–7.60death7/982/46CCAP-2 Thorlaci.. (DB RCT)−735%8.35 · 0.47–148death5/980/46CCAP-2 Thorlaci.. (DB RCT)−37%1.37 · 0.29–6.52ventilation6/942/43CCAP-2 Thorlaci.. (DB RCT)−31%1.31 · 0.45–3.82ICU12/894/39CCAP-2 Thorlaci.. (DB RCT)−41%1.41 · 0.72–2.097-point status98 (n)46 (n)CCAP-2 Manzini (DB RCT)−25%1.25 · 0.61–2.57death14/6012/60PLACO COVID Manzini (DB RCT)−10%1.10 · 0.61–1.95death/int.17/5914/56PLACO COVID Manzini (DB RCT)−6%1.06 · 0.70–1.61viral time60 (n)60 (n)PLACO COVID Self (DB RCT)−3%1.03 · 0.73–1.44death89/48280/465PassItOn Self (DB RCT)−26%1.26 · 0.81–1.90death63/48248/465PassItOn Self (DB RCT)−4%1.04 · 0.82–1.337-point status487 (n)473 (n)PassItOn Higgins (RCT)1%0.99 · 0.86–1.14death370/944324/790REMAP-CAPICU patients Denkinger (RCT)8%0.92 · 0.75–1.11death68 (n)66 (n) Denkinger (RCT)−2%1.02 · 0.59–1.77ventilation19/6818/66 Denkinger (RCT)22%0.78 · 0.52–1.167-point status68 (n)66 (n) Baksh (DB RCT)−1%1.01 · 0.94–1.09no recov.381/538381/532 Baksh (DB RCT)−4%1.04 · 0.79–1.39PASC533 (n)528 (n) Baksh (DB RCT)9%0.91 · 0.60–1.37PASC232 (n)234 (n) Baksh (DB RCT)−18%1.18 · 0.80–1.74PASC301 (n)294 (n) Alshamrani (PSM)−14%1.14 · 0.79–1.45death24/41108/205 Alshamrani (PSM)−17%1.17 · 0.93–1.28progression34/41154/205 Alshamrani (PSM)−43%1.43 · 1.13–1.80ICU37 (n)166 (n) Alshamrani (PSM)−32%1.32 · 1.07–1.63hosp. time41 (n)205 (n) Krishnan−270%3.70 · 0.90–15.80deathcase-control study Kasten−4%1.04 · 0.49–2.21death7/1911/31 Kasten−17%1.17 · 0.43–3.15death5/197/31 Gauiran (RCT)−400%5.00 · 0.25–98.53death2/220/22Co-CLARITY Gauiran (RCT)−100%2.00 · 0.20–20.49ICU2/221/22Co-CLARITY Gauiran (RCT)−7%1.07 · 0.77–1.50hosp. time22 (n)22 (n)Co-CLARITY Lewandowski−62%1.62 · 0.88–2.98death430 (all patients) Khawaja (DB RCT)−154%2.54 · 0.11–59.64death1/370/20CP_COVID-19 Khawaja (DB RCT)73%0.27 · 0.03–2.80ventilation1/372/20CP_COVID-19 Khawaja (DB RCT)46%0.54 · 0.12–2.43ICU3/373/20CP_COVID-19 Iasella (PSM)−26%1.26 · 0.93–1.71death73/29058/290 Iasella (PSM)−1%1.01 · 0.86–1.17ventilation155/290154/290 Iasella (PSM)0%1.00 · 0.82–1.22progression118/290118/290 Shaheen (RCT)0%1.00 · 0.43–2.31death8/308/30 Safai−63%1.63 · 0.71–3.73death44 (n)1,905 (n) Cao (RCT)−224%3.24 · 1.03–10.20death36 (n)36 (n) Cao (RCT)0%1.00 · 0.07–15.38severe case1/361/36 Cao (RCT)−40%1.40 · 0.58–3.37cases36 (n)36 (n)