Abstract: medRxiv preprint doi: https://doi.org/10.1101/2020.11.25.20237883; this version posted November 29, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission. Clinical and immunological benefits of convalescent plasma therapy in severe COVID-19: insights from a single center open label randomised control trial Yogiraj Ray1,2*, Shekhar Ranjan Paul1, Purbita Bandopadhyay3, Ranit D’Rozario3, Jafar Sarif3, Abhishake Lahiri4, Debaleena Bhowmik4, Janani Srinivasa Vasudevan5, Ranjeet Maurya5, Akshay Kanakan5, Sachin Sharma5, Manish Kumar5, Praveen Singh5, Rammohan Roy1, Kausik Chaudhury1, Rajsekhar Maiti1,6, Saugata Bagchi1, Ayan Maiti1, Md. Masoom Perwez1, Abhinandan Mondal1, Avinash Tewari1, Samik Mandal1, Arpan Roy1, Moumita Saha1, Durba Biswas7, Chikam Maiti7, Sayantan Chakraborty8, Biswanath Sharma Sarkar1, Anima Haldar1, Bibhuti Saha2, Shantanu Sengupta5, Rajesh Pandey5, Shilpak Chatterjee3, Prasun Bhattacharya7, Sandip Paul4, Dipyaman Ganguly3*. 1 2 Infectious Disease & Beleghata General Hospital, Kolkata, India Department of Tropical Medicine, School of Tropical Medicine, Kolkata, India 3 IICB-Translational Research Unit of Excellence, CSIR-Indian Institute of Chemical Biology, Kolkata, India 4 Division of Structural Biology & Bioinformatics, CSIR-Indian Institute of Chemical Biology, Kolkata, India 5 CSIR-Institute of Genomics and Integrative Biology, Delhi, India 6 Department of Pediatrics, Sagar Dutta Hospital & College of Medicine, Kolkata, India 7 Department of Immunohematology & Blood Transfusion, Medical College Hospital, Kolkata, India 8 Department of Critical Care Medicine, Tata Medical Center, Kolkata, India. *Correspondence: Dipyaman@iicb.res.in, jaggs.nbmc@gmail.com 1 NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice. medRxiv preprint doi: https://doi.org/10.1101/2020.11.25.20237883; this version posted November 29, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission. Abstract