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Early transfusIon of COVID-19 Convalescent Plasma in Elderly COVID-19 Patients to Prevent Disease Progression

Teofili et al., NCT04374526, LIFESAVER, NCT04374526
May 2021  
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Mortality -100% Improvement Relative Risk Conv. Plasma  LIFESAVER  LATE TREATMENT  RCT Is late treatment with convalescent plasma beneficial for COVID-19? RCT 29 patients in Italy Trial underpowered to detect differences c19early.org Teofili et al., NCT04374526, May 2021 Favorsconv. plasma Favorscontrol 0 0.5 1 1.5 2+
RCT 12 patients in Italy, showing no significant difference with convalescent plasma treatment. Results are from Axfors et al..
risk of death, 100% higher, RR 2.00, p = 1.00, treatment 1 of 4 (25.0%), control 1 of 8 (12.5%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Teofili et al., 26 May 2021, Randomized Controlled Trial, Italy, preprint, 1 author, trial NCT04374526 (history) (LIFESAVER).
This PaperConv. PlasmaAll
Late treatment
is less effective
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