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0 0.5 1 1.5 2+ Mortality 86% Improvement Relative Risk ICU admission 25% Hospitalization 54% c19early.org/cp Sullivan et al. NCT04373460 Conv. Plasma RCT LATE Favors conv. plasma Favors control
Early Outpatient Treatment for Covid-19 with Convalescent Plasma
Sullivan et al., New England Journal of Medicine, doi:10.1056/NEJMoa2119657 (date from earlier preprint), NCT04373460 (history)
21 Dec 2021    Source   PDF   Share   Tweet
RCT 1,181 outpatients in the USA, mean 6 days from symptom onset, showing lower hospitalization with treatment. NCT04373460 (history).
risk of death, 85.7% lower, RR 0.14, p = 0.12, treatment 0 of 592 (0.0%), control 3 of 589 (0.5%), NNT 196, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of ICU admission, 25.4% lower, RR 0.75, p = 0.73, treatment 3 of 592 (0.5%), control 4 of 589 (0.7%), NNT 580.
risk of hospitalization, 54.3% lower, RR 0.46, p = 0.005, treatment 17 of 592 (2.9%), control 37 of 589 (6.3%), NNT 29.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sullivan et al., 21 Dec 2021, Double Blind Randomized Controlled Trial, USA, peer-reviewed, 58 authors, study period 3 June, 2020 - 1 October, 2021, average treatment delay 6.0 days, trial NCT04373460 (history).
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Late treatment
is less effective
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