COVID-19 Convalescent Plasma Therapy: Long Term Implications
Hyunah Yoon, Yi Li, Keith S Goldfeld, Gia F Cobb, Caroline L Sturm-Reganato, Luis Ostrosky-Zeichner, Dushyantha T Jayaweera, Julie V Philley, Mahalia S Desruisseaux, Marla J Keller, Judith S Hochman, Liise-Anne Pirofski, MD Mila B Ortigoza, Judith S Hochman, Bruce N Cronstein, Deborah Keeling, Norka Rappoport, Jenna Saraga, James Holahan, MD Mila B Ortigoza, Liise-Anne Pirofski, Hyunah Yoon, Caroline L Sturm-Reganato, Gia F Cobb, Rakshit Andela, Yousef Darwish, Monica R Taveras, Patrick S Xin, Jeff Lafleur, Levi Cleare, Keith S Goldfeld, Yi Li, MD Mila B Ortigoza, Mary L O’keeffe, Gia F Cobb, Caroline L Sturm-Reganato, Fatema Z Rahman, Adeyinka O Ajayi, Sara L Rodriguez, Eduardo Iturrate, Jacqueline M Gallagher, Ololade E Thomas, Danibel Ramos, Charlotte C Fong, Liise-Anne Pirofski, Hyunah Yoon, Marla J Keller, Andrea A Asencio, Isaiah Eke, James Castro, Jidong Shan, Alex Chalco, Jeff Lafleur, Levi Cleare, Mahalia S Desruisseaux, Grace M Cortezzo, Erica Rocco, Oscar Bate Akide Ndunge, Catherine Parmelee, Gina Solomon, Staci Cahil, Dushyantha T Jayaweera, Chin Chin Lee, Daru L Ransford, Deniz Dasmany, Andres Corona, Kenia Moreno, Gledys L Martinez, Christopher Otero, David D Mcpherson, Luis Ostrosky-Zeichner, Bela Patel, Masayuki Nigo, Ryan M Huebinger, Goutham Dronavalli, Carolyn Z Grimes, Virginia E Umana, Maria D Hernandez, Laura E Nielsen, Taylor P Stutz, Mehriban Mammadova, Andrew N Dentino, Timothy R Heath, Jessica G Martin, Fatimah O Bello, Erik Hinojosa, Julie V Philley, Megan S Devine, Rebekah L Hibbard, Anne M Ford
Open Forum Infectious Diseases, doi:10.1093/ofid/ofad686
Background. The long-term effect of coronavirus disease 2019 (COVID-19) acute treatments on postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC) is unknown. The CONTAIN-Extend study explores the long-term impact of COVID-19 convalescent plasma (CCP) therapy on postacute sequelae of SARS-CoV-2 infection (PASC) symptoms and general health 18 months following hospitalization. Methods. The CONTAIN-Extend study examined 281 participants from the original CONTAIN COVID-19 trial (CONTAIN-RCT, NCT04364737) at 18 months post-hospitalization for acute COVID-19. Symptom surveys, global health assessments, and biospecimen collection were performed from November 2021 to October 2022. Multivariable logistic and linear regression estimated associations between the randomization arms and self-reported symptoms and Patient-Reported Outcomes Measurement Information System (PROMIS) scores and adjusted for covariables, including age, sex, race/ethnicity, disease severity, and CONTAIN enrollment quarter and sites. Results. There were no differences in symptoms or PROMIS scores between CCP and placebo (adjusted odds ratio [aOR] of general symptoms, 0.95; 95% CI, 0.54-1.67). However, females (aOR, 3.01; 95% CI, 1.73-5.34), those 45-64 years (aOR, 2.55; 95% CI, 1.14-6.23), and April-June 2020 enrollees (aOR, 2.39; 95% CI, 1.10-5.19) were more likely to report general symptoms and have poorer PROMIS physical health scores than their respective reference groups. Hispanic participants (difference, -3.05; 95% CI, -5.82 to -0.27) and Black participants (-4.48; 95% CI, -7.94 to -1.02) had poorer PROMIS physical health than White participants. Conclusions. CCP demonstrated no lasting effect on PASC symptoms or overall health in comparison to the placebo. This study underscores the significance of demographic factors, including sex, age, and timing of acute infection, in influencing symptom reporting 18 months after acute hypoxic COVID-19 hospitalization.
Supplementary Data Supplementary materials are available online. Supplementary materials consist of data provided by the author that are published to benefit the reader. The posted materials are not copyedited. The contents of all supplementary data are the sole responsibility of the authors. Questions or messages regarding errors should be addressed to the author.
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'abstract': '<jats:title>Abstract</jats:title>\n'
' <jats:sec>\n'
' <jats:title>Background</jats:title>\n'
' <jats:p>The long-term effect of Coronavirus Disease 2019 (COVID-19) acute '
'treatments on post-acute sequelae of SARS-CoV-2 infection (PASC) is unknown. The '
'CONTAIN-Extend study explores the long-term impact of COVID-19 convalescent plasma (CCP) '
'therapy on Post-Acute Sequelae of SARS-CoV-2 infection (PASC) symptoms and general health 18 '
'months following hospitalization.</jats:p>\n'
' </jats:sec>\n'
' <jats:sec>\n'
' <jats:title>Methods</jats:title>\n'
' <jats:p>The CONTAIN-Extend study examined 281 participants from the '
'original CONTAIN COVID-19 trial (CONTAIN-RCT, NCT04364737) at 18 months post-hospitalization '
'for acute COVID-19. Symptom surveys, global health assessments, and biospecimen collection '
'was performed from November 2021 to October 2022. Multivariable logistic and linear '
'regression estimated associations between the randomization arms and self-reported symptoms '
'and PROMIS scores, adjusted for covariables, including age, sex, race/ethnicity, disease '
'severity, and CONTAIN enrollment quarter and sites.</jats:p>\n'
' </jats:sec>\n'
' <jats:sec>\n'
' <jats:title>Results</jats:title>\n'
' <jats:p>There were no differences in symptoms or PROMIS scores between CCP '
'and placebo (adjusted odds ratio of general symptoms, 0.95; 95% confidence intervals, 0.54, '
'1.67). However, females (3.01; 1.73, 5.34), those 45-64 years (2.55; 1.14, 6.23), and '
'April-June 2020 enrollees (2.39; 1.10, 5.19) were more likely to report general symptoms and '
'have poorer PROMIS physical health scores than their respective reference groups. Hispanic '
'participants (difference, -3.05; 95% CI, -5.82, -0.27) and Black participants (-4.48; -7.94, '
'-1.02) had poorer PROMIS physical health than White participants.</jats:p>\n'
' </jats:sec>\n'
' <jats:sec>\n'
' <jats:title>Conclusions</jats:title>\n'
' <jats:p>CCP demonstrated no lasting effect on PASC symptoms or overall '
'health in comparison to the placebo. This study underscores the significance of demographic '
'factors, including sex, age, and the timing of acute infection, in influencing symptom '
'reporting 18 months after acute hypoxic COVID-19 hospitalization.</jats:p>\n'
' </jats:sec>',
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