Conv. Plasma
Nigella Sativa
Peg.. Lambda

All chlorhexidine studies
Meta analysis
Home COVID-19 treatment researchChlorhexidineChlorhexidine (more..)
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta
Cannabidiol Meta Molnupiravir Meta
Colchicine Meta
Conv. Plasma Meta
Curcumin Meta Nigella Sativa Meta
Ensovibep Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Peg.. Lambda Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Ivermectin Meta
Lactoferrin Meta

All Studies   All Outcomes   Recent:  
0 0.5 1 1.5 2+ Viral clearance, spray and.. 85% Improvement Relative Risk Viral clearance, rinse only 60% Chlorhexidine  Huang et al.  LATE TREATMENT  RCT Is late treatment with chlorhexidine beneficial for COVID-19? RCT 173 patients in the USA (May - December 2020) Improved viral clearance with chlorhexidine (p<0.000001) Huang et al., J. Medical Virology, Apr 2021 Favors chlorhexidine Favors control

Use of chlorhexidine to eradicate oropharyngeal SARS‐CoV‐2 in COVID‐19 patients

Huang et al., Journal of Medical Virology, doi:10.1002/jmv.26954
Apr 2021  
  Source   PDF   All Studies   Meta AnalysisMeta
RCT 294 hospitalized patients in the USA, showing faster oropharyngeal viral clearance with chlorhexidine. Results were better with a combination of oropharyngeal rinse and posterior oropharyngeal spray compared with the rinse alone.
Targeted administration to the respiratory tract provides treatment directly to the typical source of initial SARS-CoV-2 infection and replication, and allows for rapid onset of action, higher local drug concentration, and reduced systemic side effects (early treatment may be more beneficial).
risk of no viral clearance, 85.1% lower, RR 0.15, p < 0.001, treatment 13 of 93 (14.0%), control 75 of 80 (93.8%), NNT 1.3, oropharyngeal rinse and spray, day 4.
risk of no viral clearance, 59.9% lower, RR 0.40, p < 0.001, treatment 25 of 66 (37.9%), control 52 of 55 (94.5%), NNT 1.8, oropharyngeal rinse only, day 4.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Huang et al., 30 Apr 2021, Randomized Controlled Trial, USA, peer-reviewed, median age 62.0, 2 authors, study period 20 May, 2020 - 15 December, 2020.
All Studies   All Outcomes   Submit Updates or Corrections
This PaperChlorhexidineAll
Use of chlorhexidine to eradicate oropharyngeal SARS‐CoV‐2 in COVID‐19 patients
Y Hanna Huang, MD Jong T Huang
Journal of Medical Virology, doi:10.1002/jmv.26954
As public distribution of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is underway, prevention of coronavirus disease 2019 (COVID-19) relies on minimizing spread. In this study, chlorhexidine gluconate was investigated as a topical antimicrobial agent against SARS-CoV-2. This was a randomized, prospective cohort study using chlorhexidine as an oral rinse and posterior oropharyngeal spray in hospitalized COVID-19 patients. The primary outcome was presence or absence of laboratory-confirmed SARS-CoV-2 in the oral and oropharyngeal cavities after 4 days of chlorhexidine use and standard of care (study group) or standard of care only (control group). SARS-CoV-2 was eliminated from the oropharynx in 62.1% of patients who used chlorhexidine as an oral rinse, versus 5.5% of the control group patients. Among patients who used a combination of oral rinse and oropharyngeal spray, 86.0% eliminated oropharyngeal SARS-CoV-2, versus 6.3% of control patients. Chlorhexidine is a simple and safe addition to current COVID-19 prevention guidelines and may play a significant role in reducing disease spread.
CONFLICT OF INTERESTS The authors declare that there are no conflict of interests.
Anderson, Podgorny, Berríos-Torres, Strategies to prevent surgical site infections in acute care hospitals: 2014 update, Infect Control Hosp Epidemiol
Carrouel, Gonçalves, Conte, Antiviral activity of reagents in mouth rinses against SARS-CoV-2, J Dent Res, doi:10.1177/0022034520967933
Denton, Chlorhexidine, Disinfection, Sterilization and Preservation
Dhand, Li, Coughs and sneezes: their role in transmission of respiratory viral infections, including SARS-CoV-2, Am J Respir Crit Care Med
Firestone, Lorentz, Wang, First identified cases of SARS-CoV-2 variant B.1.1.7 in Minnesota -December 2020-January 2021, Morb Mortal Wkly Rep
Houston, Hougland, Anderson, Larocco, Kennedy et al., Effectiveness of 0.12% chlorhexidine gluconate oral rinse in reducing prevalence of nosocomial pneumonia in patients undergoing heart surgery, Am J Crit Care
Jones, Chlorhexidine: is it still the gold standard?, Periodontol
Khokhar, Roy, Purohit, Goyal, Setia, Viricidal treatments for prevention of coronavirus infection, Pathog Glob Health
Liu, Yan, Wan, Viral dynamics in mild and severe cases of COVID-19, Lancet Infect Dis
Meyers, Robison, Milici, Lowering the transmission and spread of human coronavirus, J Med Virol
Yoon, Yoon, Song, Clinical significance of a high SARS-CoV-2 viral load in the saliva, J Korean Med Sci
Late treatment
is less effective
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop