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0 0.5 1 1.5 2+ Progression -1% Improvement Relative Risk Recovery time 11% Nitric Oxide  Bryan et al.  EARLY TREATMENT  DB RCT Is early treatment with nitric oxide beneficial for COVID-19? Double-blind RCT 524 patients in the USA (November 2020 - November 2022) Faster recovery with nitric oxide (not stat. sig., p=0.3) Bryan et al., The American J. Medicine, Jun 2023 Favors nitric oxide Favors control

The Efficacy of Nitric Oxide Generating Lozenges on Outcome in Newly Diagnosed COVID-19 Patients of African American and Hispanic Origin

Bryan et al., The American Journal of Medicine, doi:10.1016/j.amjmed.2023.05.021, NCT04601077
Jun 2023  
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RCT 524 outpatients in the USA for a nitric oxide generating lozenge, showing no significant difference in combined hospitalization, ICU admission, intubation, dialysis, and death. There were only 3 events in each arm, all occuring in 2020, with zero events in 2021 or 2022. Recovery was 11% faster with treatment, without statistical significance. Authors note that a higher dose may have been more effective. Trials showing greater efficacy have used a nasal spray.
risk of progression, 0.8% higher, RR 1.01, p = 1.00, treatment 3 of 261 (1.1%), control 3 of 263 (1.1%), combined hospitalization, ICU admission, intubation, dialysis, and death.
recovery time, 11.2% lower, relative time 0.89, p = 0.30, treatment 261, control 263.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bryan et al., 24 Jun 2023, Double Blind Randomized Controlled Trial, placebo-controlled, USA, peer-reviewed, 3 authors, study period 1 November, 2020 - 30 November, 2022, trial NCT04601077 (history).
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The Efficacy of Nitric Oxide Generating Lozenges on Outcome in Newly Diagnosed COVID-19 Patients of African American and Hispanic Origin
PhD Nathan S Bryan, MD Janos Molnar, MD. c a. John Somberg
The American Journal of Medicine, doi:10.1016/j.amjmed.2023.05.021
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
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