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The Efficacy of Nitric Oxide Generating Lozenges on Outcome in Newly Diagnosed COVID-19 Patients of African American and Hispanic Origin

Bryan et al., The American Journal of Medicine, doi:10.1016/j.amjmed.2023.05.021, NCT04601077
Jun 2023  
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Progression -1% Improvement Relative Risk Recovery time 11% Nitric Oxide  Bryan et al.  EARLY TREATMENT  DB RCT Is early treatment with nitric oxide beneficial for COVID-19? Double-blind RCT 524 patients in the USA (November 2020 - November 2022) Faster recovery with nitric oxide (not stat. sig., p=0.3) c19early.org Bryan et al., The American J. Medicine, Jun 2023 Favorsnitric oxide Favorscontrol 0 0.5 1 1.5 2+
RCT 524 outpatients in the USA for a nitric oxide generating lozenge, showing no significant difference in combined hospitalization, ICU admission, intubation, dialysis, and death. There were only 3 events in each arm, all occuring in 2020, with zero events in 2021 or 2022. Recovery was 11% faster with treatment, without statistical significance. Authors note that a higher dose may have been more effective. Trials showing greater efficacy have used a nasal spray.
risk of progression, 0.8% higher, RR 1.01, p = 1.00, treatment 3 of 261 (1.1%), control 3 of 263 (1.1%), combined hospitalization, ICU admission, intubation, dialysis, and death.
recovery time, 11.2% lower, relative time 0.89, p = 0.30, treatment 261, control 263.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bryan et al., 24 Jun 2023, Double Blind Randomized Controlled Trial, placebo-controlled, USA, peer-reviewed, 3 authors, study period 1 November, 2020 - 30 November, 2022, trial NCT04601077 (history). Contact: johnsomberg@comcast.net.
This PaperNitric OxideAll
The Efficacy of Nitric Oxide Generating Lozenges on Outcome in Newly Diagnosed COVID-19 Patients of African American and Hispanic Origin
PhD Nathan S Bryan, MD Janos Molnar, MD. c a. John Somberg
The American Journal of Medicine, doi:10.1016/j.amjmed.2023.05.021
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
References
Akaberi, Krambrich, Ling, Å. Mitigation of the replication of SARS-CoV-2 by nitric oxide in vitro, Redox Biol
Akerström, Gunalan, Keng, Tan, Mirazimi, Dual effect of nitric oxide on SARS-CoV replication: viral RNA production and palmitoylation of the S protein are affected, Virology
Allen, Stamler, Piantadosi, Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation, Trends Mol Med
Alqahtani, Aldhahir, Ghamdi, Inhaled Nitric Oxide for Clinical Management of COVID-19: A Systematic Review and Meta-Analysis, Int J Environ Res Public Health
Bagate, Tuffet, Masi, Perier, Rescue therapy with inhaled nitric oxide and almitrine in COVID-19 patients with severe acute respiratory distress syndrome, Ann Intensive Care
Benedetto, Romano, Baca, Inhaled nitric oxide in cardiac surgery: Evidence or tradition?, Nitric Oxide
Bryan, Tribble, Angelov, Oral Microbiome and Nitric Oxide: the Missing Link in the Management of Blood Pressure, Curr Hypertens Rep
Carnethon, Pu, Howard, Cardiovascular Health in African Americans: A Scientific Statement from the American Heart Association
Covid, Tracker, None
Covid, Tracker, None
Dellinger, Zimmerman, Taylor, Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome: results of a randomized phase II trial. Inhaled nitric oxide in ARDS study group, Crit Care Med
Ferrari, Santini, Protti, Inhaled nitric oxide in mechanically ventilated patients with COVID-19, J Crit Care
Furchgott, Zawadzki, The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine, Nature
Garfield, Mcfadyen, Briar, Potential for personalised application of inhaled nitric oxide in COVID-19 pneumonia, Br J Anaesth
Gebistorf, Karam, Wetterslev, Afshari, Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) in children and adults, Cochrane Database Syst Rev
Higgins, Berry, Lorenzi, Murthy, Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial
Ignarro, Inhaled NO and COVID-19, Br J Pharmacol
Inomax, gas, for inhalation. FDA approved label
Lotz, Muellenbach, Meybohm, Effects of inhaled nitric oxide in COVID-19-induced ARDS -Is it worthwhile?, Acta Anaesthesiol Scand
Marletta, Yoon, Iyengar, Leaf, Wishnok, Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate, Biochemistry
Mcknight, Smith, Drummond, Duncan, Golden et al., Chemical synthesis of nitric oxide in the stomach from dietary nitrate in humans, Gut
Moncada, Higgs, The discovery of nitric oxide and its role in vascular biology, Br J Pharmacol
Radomski, Palmer, Moncada, The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide, Br J Pharmacol
Schmid, Bürki, Engel, Schmidlin, Tornic et al., Inhaled nitric oxide versus intravenous vasodilators in severe pulmonary hypertension after cardiac surgery, Anesth Analg
Shi, Qin, Shen, Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, JAMA Cardiol
Sulaiman, Korayem, Altebainawi, Evaluation of inhaled nitric oxide (iNO) treatment for moderate-to-severe ARDS in critically ill patients with COVID-19: a multicenter cohort study, Crit Care
Vives, Gascó, Pla, Inhaled Nitric Oxide in Acute Severe Pulmonary Hypertension and Severe Acute Respiratory Distress Syndrome Secondary to COVID-19 Pneumonia: A Case Report, Am J Case Rep
Welker, Huang, Gil, Ramakrishna, 2021 Acute Respiratory Distress Syndrome Update, With Coronavirus Disease, J Cardiothorac Vasc Anesth
Witek, Lakhkar, Nitric Oxide
Yancy, COVID-19 and African Americans, JAMA
Zhang, Hess, Qian, Hemoglobin βCys93 is essential for cardiovascular function and integrated response to hypoxia, Proc Natl Acad Sci U S A
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