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0 0.5 1 1.5 2+ Mortality 90% Improvement Relative Risk Ventilation 90% <2 point WOS improvem.. 42% Time to viral load reduc.. 64% Time to viral load r.. (b) 63% c19early.org/no Moni et al. ISRCTN16806663 Nitric Oxide RCT ICU Favors nitric oxide Favors control
Clinical Efficacy of Inhaled Nitric Oxide in Preventing the Progression of Moderate to Severe COVID-19 and Its Correlation to Viral Clearance: Results of a Pilot Study
Moni et al., Infectious Microbes and Diseases, doi:10.1097/IM9.0000000000000079 (date from earlier preprint), ISRCTN16806663
20 Apr 2021    Source   PDF   Share   Tweet
RCT 29 ICU patients in India, showing improved clinical outcomes and faster viral clearance with inhaled nitric oxide treatment. The treatment group was younger (mean 54 vs. 66) and had more patients on NIV at baseline (29% vs. 18%).
risk of death, 90.1% lower, RR 0.10, p = 0.03, treatment 0 of 14 (0.0%), control 4 of 11 (36.4%), NNT 2.8, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 28.
risk of mechanical ventilation, 90.1% lower, RR 0.10, p = 0.03, treatment 0 of 14 (0.0%), control 4 of 11 (36.4%), NNT 2.8, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 28.
risk of <2 point WOS improvement, 42.5% better, RR 0.58, p = 0.47, treatment 3 of 14 (21.4%), control 7 of 11 (63.6%), NNT 2.4, adjusted per study, inverted to make RR<1 favor treatment, odds ratio converted to relative risk, day 14.
time to viral load reduction, 64.4% lower, RR 0.36, p = 0.005, treatment 14, control 11, adjusted per study, inverted to make RR<1 favor treatment, N gene.
time to viral load reduction, 63.4% lower, RR 0.37, p = 0.005, treatment 14, control 11, adjusted per study, inverted to make RR<1 favor treatment, Orf1ab gene.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Moni et al., 20 Apr 2021, Randomized Controlled Trial, India, peer-reviewed, 16 authors, study period September 2020 - December 2020, average treatment delay 6.78 days, trial ISRCTN16806663.
Contact: jayant.aveek@gmail.com.
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