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All Studies   Meta Analysis       

Retrospective clinical study for COVID-19 prevention after exposure

SaNOtize
Apr 2022  
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Case 75% Improvement Relative Risk Nitric Oxide  SaNOtize et al.  Prophylaxis Does nitric oxide reduce COVID-19 infections? Retrospective 625 patients in Thailand Fewer cases with nitric oxide (p<0.000001) c19early.org SaNOtize, April 2022 Favorsnitric oxide Favorscontrol 0 0.5 1 1.5 2+
PEP retrospective 625 university students in Thailand offered nitric oxide nasal spray, showing significantly lower cases for students that chose to use the treatment.
Targeted administration to the respiratory tract provides treatment directly to the typical source of initial SARS-CoV-2 infection and replication, and allows for rapid onset of action, higher local drug concentration, and reduced systemic side effects.
risk of case, 75.0% lower, RR 0.25, p < 0.001, treatment 13 of 203 (6.4%), control 108 of 422 (25.6%), NNT 5.2.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
SaNOtize et al., 30 Apr 2022, retrospective, Thailand, preprint, 1 author.
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