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Systolic Pulmonary Artery Pressure as Long-Term Mortality Predictor in Elderly Critically Ill with Severe COVID-19 Pneumonia

Kurnik et al., Viruses, doi:10.3390/v17020244
Feb 2025  
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Mortality 23% Improvement Relative Risk Nitric Oxide for COVID-19  Kurnik et al.  ICU PATIENTS Is very late treatment with nitric oxide beneficial for COVID-19? Retrospective 130 patients in Slovenia (October 2020 - April 2021) Lower mortality with nitric oxide (not stat. sig., p=0.33) c19early.org Kurnik et al., Viruses, February 2025 Favorsnitric oxide Favorscontrol 0 0.5 1 1.5 2+
39th treatment shown to reduce risk in June 2022, now with p = 0.046 from 13 studies, recognized in 10 countries.
Lower risk for cases and viral clearance.
No treatment is 100% effective. Protocols combine treatments.
5,500+ studies for 119 treatments. c19early.org
Retrospective 130 elderly (≥70 years) critically ill COVID-19 patients showing no significant difference in long-term mortality with nitric oxide.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
Study covers nitric oxide and aspirin.
risk of death, 22.7% lower, RR 0.77, p = 0.33, treatment 3 of 5 (60.0%), control 97 of 125 (77.6%), NNT 5.7, day 1000.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Kurnik et al., 11 Feb 2025, retrospective, Slovenia, peer-reviewed, mean age 76.8, 3 authors, study period October 2020 - April 2021. Contact: marko.kurnik@sb-celje.si (corresponding author), helena.bozic@sb-celje.si, matej.podbregar@sb-celje.si.
This PaperNitric OxideAll
DOI record: { "DOI": "10.3390/v17020244", "ISSN": [ "1999-4915" ], "URL": "http://dx.doi.org/10.3390/v17020244", "abstract": "<jats:p>Background: COVID-19 can cause acute pulmonary hypertension (PH), worsening outcomes in critically ill elderly patients. Point-of-care ultrasound (POCUS), assessing right ventricular hemodynamics, predicts short-term outcomes. This study examines the long-term impact of acute PH on mortality in elderly COVID-19 patients. Methods: This retrospective long-term study analyzed data from patients over 70 years old with severe COVID-19 pneumonia admitted to a mixed 25-bed, level 3 intensive care unit (ICU). POCUS focused on systolic pulmonary artery pressure (sPAP) at admission. Mortality was evaluated 1000 days post-admission. Results: The study included 130 patients, comprising 30 long-term survivors and 100 non-survivors, with a cumulative long-term mortality rate of 77%. Non-survivors had significantly higher sPAP values (39.1 ± 12.8 vs. 30.4 ± 9.2, p = 0.04), which were associated with long-term mortality in survival analysis. Conclusion: Acute pulmonary hypertension (PH), reflected by elevated systolic pulmonary artery pressure (sPAP), is strongly associated with long-term mortality in elderly critically ill COVID-19 patients. Early assessment of sPAP via POCUS may help identify high-risk patients and guide management strategies to improve outcomes.</jats:p>", "alternative-id": [ "v17020244" ], "author": [ { "ORCID": "https://orcid.org/0000-0002-9433-2035", "affiliation": [ { "name": "Department of Internal Intensive Medicine, General Hospital Celje, 3000 Celje, Slovenia" } ], "authenticated-orcid": false, "family": "Kurnik", "given": "Marko", "sequence": "first" }, { "affiliation": [ { "name": "Department of Internal Intensive Medicine, General Hospital Celje, 3000 Celje, Slovenia" } ], "family": "Božič", "given": "Helena", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Internal Intensive Medicine, General Hospital Celje, 3000 Celje, Slovenia" }, { "name": "Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia" } ], "family": "Podbregar", "given": "Matej", "sequence": "additional" } ], "container-title": "Viruses", "container-title-short": "Viruses", "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2025, 2, 11 ] ], "date-time": "2025-02-11T14:36:05Z", "timestamp": 1739284565000 }, "deposited": { "date-parts": [ [ 2025, 2, 13 ] ], "date-time": "2025-02-13T05:50:41Z", "timestamp": 1739425841000 }, "indexed": { "date-parts": [ [ 2025, 2, 13 ] ], "date-time": "2025-02-13T06:10:15Z", "timestamp": 1739427015218, "version": "3.37.0" }, "is-referenced-by-count": 0, "issue": "2", "issued": { "date-parts": [ [ 2025, 2, 11 ] ] }, "journal-issue": { "issue": "2", "published-online": { "date-parts": [ [ 2025, 2 ] ] } }, "language": "en", "license": [ { "URL": "https://creativecommons.org/licenses/by/4.0/", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2025, 2, 11 ] ], "date-time": "2025-02-11T00:00:00Z", "timestamp": 1739232000000 } } ], "link": [ { "URL": "https://www.mdpi.com/1999-4915/17/2/244/pdf", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "1968", "original-title": [], "page": "244", "prefix": "10.3390", "published": { "date-parts": [ [ 2025, 2, 11 ] ] }, "published-online": { "date-parts": [ [ 2025, 2, 11 ] ] }, "publisher": "MDPI AG", "reference": [ { "DOI": "10.1016/S0140-6736(20)30183-5", "article-title": "Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China", "author": "Huang", "doi-asserted-by": "crossref", "first-page": "497", "journal-title": "Lancet", "key": "ref_1", "volume": "395", "year": "2020" }, { "DOI": "10.1183/13993003.01913-2018", "article-title": "Haemodynamic definitions and updated clinical classification of pulmonary hypertension", "author": "Simonneau", "doi-asserted-by": "crossref", "first-page": "1801913", "journal-title": "Eur. 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Late treatment
is less effective
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