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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Improvement 42% Improvement Relative Risk Viral load 51% c19early.org/no Winchester et al. Nitric Oxide for COVID-19 RCT EARLY Favors nitric oxide Favors control
Clinical efficacy of nitric oxide nasal spray (NONS) for the treatment of mild COVID-19 infection
Winchester et al., Journal of Infection, doi:10.1016/j.jinf.2021.05.009
13 May 2021    Source   PDF   Share   Tweet
RCT with 40 nitric oxide and 40 placebo patients in the UK, showing faster viral clearance and greater improvement with treatment.
risk of no improvement, 42.0% lower, RR 0.58, p = 0.008, treatment 8 of 15 (53.3%), control 23 of 25 (92.0%), NNT 2.6.
viral load, 51.3% lower, relative load 0.49, p = 0.001, treatment 40, control 40, AUC relative mean change.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Winchester et al., 13 May 2021, Double Blind Randomized Controlled Trial, placebo-controlled, United Kingdom, peer-reviewed, 4 authors.
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