C6-iPrO penam for COVID-19
COVID-19 involves the interplay of 350+ viral and host proteins and factors providing many therapeutic targets.
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, C6-Alkoxy substituted penicillins are potent non-covalently binding inhibitors of the SARS-CoV-2 main protease, RSC Medicinal Chemistry, doi:10.1039/d5md00789e
Introduction of a C6-alkoxy group on the penicillin scaffold can alter the mechanism of SARS-CoV-2 main protease (M pro ) inhibition.