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c19early.org COVID-19 treatment researchTrimodulinTrimodulin (more..)
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Colchicine Meta Nigella Sativa Meta
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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ ESsCOVID Agafina (DB RCT) -17% 1.17 [0.63-2.16] death 18/84 15/82 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.63 Late treatment -17% 1.17 [0.63-2.16] 18/84 15/82 17% higher risk All studies -17% 1.17 [0.63-2.16] 18/84 15/82 17% higher risk 1 trimodulin COVID-19 study c19early.org September 2024 Tau​2 = 0.00, I​2 = 0.0%, p = 0.63 Effect extraction pre-specified(most serious outcome) Favors trimodulin Favors control
Aug 13
Agafina et al., European Journal of Medical Research, doi:10.1186/s40001-024-02008-x Efficacy and safety of trimodulin in patients with severe COVID-19: results from a randomised, placebo-controlled, double-blind, multicentre, phase II trial (ESsCOVID)
17% higher mortality (p=0.7), 2% lower progression (p=1), and 9% longer ventilation (p=0.62). RCT 166 severe COVID-19 patients on non-invasive ventilation or high-flow oxygen showing no significant difference in clinical deterioration or mortality with trimodulin treatment compared to placebo. In a post hoc analysis of a subgroup ..
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