Mangiferin for COVID-19

 Mangiferin has been reported as potentially beneficial for COVID-19 in the following studies.
COVID-19 involves the interplay of 350+ viral and host proteins and factors providing many therapeutic targets. Scientists have proposed 10,000+ potential treatments. c19early.org analyzes 210+ treatments. We have not reviewed mangiferin in detail.
Yang et al., Identification and validation of programmed cell death related biomarkers for the treatment and prevention COVID-19, Annals of Medicine, doi:10.1080/07853890.2025.2492830
Chowdhury et al., Exploring Natural Plant Compounds Against the SARS-CoV-2 Spike Protein: An Analytical and Computational Approach for Drug Discovery, Pharmacological Research - Natural Products, doi:10.1016/j.prenap.2025.100191
Zeng et al., Jinhua Qinggan Granule UHPLC-Q-extractive-Orbitrap-MS assay: Putative identification of 45 potential anti-Covid-19 constituents, confidential addition, and pharmacopoeia quality-markers recommendation, Journal of Food and Drug Analysis, doi:10.38212/2224-6614.3466
unknown, u., Trainee Poster Honorable Mention Poster Abstracts Presented at the 123rd Annual Meeting of the American Association of Colleges of Pharmacy, July 23-27, 2022, American Journal of Pharmaceutical Education, doi:10.5688/ajpe9169
Kawall et al., Inhibitory effect of phytochemicals towards SARS-CoV-2 papain like protease (PLpro) proteolytic and deubiquitinase activity, Frontiers in Chemistry, doi:10.3389/fchem.2022.1100460
Graphical AbstractInhibition of proteolytic and deubiquitinase activity of SARS-CoV-2 PLpro enzyme by phytochemicals.