Nigellamine D for COVID-19
c19early.org
COVID-19 Treatment Clinical Evidence
COVID-19 involves the interplay of 400+ viral and host proteins and factors, providing many therapeutic targets.
c19early analyzes 6,000+ studies for 210+ treatments—over 17 million hours of research.
Only three high-profit early treatments are approved in the US.
In reality, many treatments reduce risk,
with 25 low-cost treatments approved across 163 countries.
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Naso/
oropharyngeal treatment Effective Treatment directly to the primary source of initial infection. -
Healthy lifestyles Protective Exercise, sunlight, a healthy diet, and good sleep all reduce risk.
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Immune support Effective Vitamins A, C, D, and zinc show reduced risk, as with other viruses.
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Thermotherapy Effective Methods for increasing internal body temperature, enhancing immune system function.
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Systemic agents Effective Many systemic agents reduce risk, and may be required when infection progresses.
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High-profit systemic agents Conditional Effective, but with greater access and cost barriers.
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Monoclonal antibodies Limited Utility Effective but rarely used—high cost, variant dependence, IV/SC admin.
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Acetaminophen Harmful Increased risk of severe outcomes and mortality.
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Remdesivir Harmful Increased mortality with longer followup. Increased kidney and liver injury, cardiac disorders.
Nigellamine D may be beneficial for
COVID-19 according to the study below.
COVID-19 involves the interplay of 400+ viral and host proteins and factors providing many therapeutic targets.
Scientists have proposed 11,000+ potential treatments.
c19early.org analyzes
210+ treatments.
We have not reviewed nigellamine D in detail.
, In silico Screening of Potential Drug Candidate against Chain a of Coronavirus Binding Protein from Major Nigella Bioactive Compounds, Asian Journal of Advanced Research and Reports, doi:10.9734/ajarr/2024/v18i7697
Background: More hazardous varieties of severe acute respiratory syndrome-related coronavirus have created major health hazards around the globe since 2019. There is no hundred percent effective drug has been developed against this virus. Bioactive compounds from plants are used as drugs or the main source of raw material for drugs against various diseases. Aims: To screen the potential drug candidate against coronavirus from major Nigella bioactive compounds. Methods and Materials: In the first step of our computational biology-dependent study, we selected six major Nigella compounds, four major drugs used in COVID-19 treatment, and a binding protein of coronavirus. In the second step, we processed the ligands and peptides and performed a docking to test the binding affinity. In the final step, we selected a compound with the highest binding affinity and performed molecular simulation, ADME/T, bioactivity, and QSAR analysis to characterize this molecule as a drug candidate. Results: Four different antiviral agents that had been used in the treatment of COVID-19 patients showed less binding affinity in molecular docking compared with six bioactive compounds of Nigella. Nigellamine C, Nigeglanine, nigellamine D, nigellicine, nigellidine, and nigellone showed binding affinity of -7.9, -7.5, -7.3, -6.5, -7, and -6.7 kcal/mol, respectively whereas ribavirin, favipiravir, remdesivir, and nirmatrelvir showed -5.1, -4.8, -6.2, and -5.9 kcal/mol, accordingly to chain A of subunit 1 (S1) of the spike protein of coronavirus. Nigellamine C showed the highest binding affinity and suitable ADME/T properties with negligible toxic properties and good drug-likeness properties. Conclusion: Nigellamine C may be a potent candidate for inhalation and/or oral drug development based on QSAR analysis and ADME/T analysis among all Nigella compounds.