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Amantadine for COVID-19
3 studies with >500 patients
Hospital Icon Control
Hospital Icon Amantadine Serious Outcome Risk
No significant improvements are seen in meta analysis to date.
COVID-19 Amantadine studies. Dec 2025. c19early.org
0 0.5 1 1.5+ All studies -19% Mortality -0% Hospitalization -67% Recovery 5% RCTs -19% RCT mortality -0% Late -19% Favorsamantadine Favorscontrol
Oct 31
2023
 Weis et al., Clinical Microbiology and Infection, doi:10.1016/j.cmi.2023.06.023 Amantadine for COVID-19 treatment (ACT) study: a randomized, double-blinded, placebo-controlled clinical trial
48% worse recovery (p=0.1). RCT 242 non-hospitalized COVID-19 patients showing no benefit of amantadine for disease progression.
Sep 14
2023
 Rejdak et al., European Journal of Neurology, doi:10.1111/ene.16045 Amantadine in unvaccinated patients with early, mild to moderate COVID‐19: A randomized, placebo‐controlled, double‐blind trial
39% improved recovery (p=0.03) and 89% lower progression (p=0.12). RCT 99 patients showing higher complete recovery rates with amantadine, but no significant difference in progression. Authors suggest amantadine's central nervous system effects may have contributed to faster recovery by reducing neuropsy..
Jun 30
2023
 Barczyk et al., Respiratory Medicine, doi:10.1016/j.rmed.2023.107198 Efficacy of oral amantadine among patients hospitalised with COVID-19: A randomised, double-blind, placebo-controlled, multicentre study
13% higher mortality (p=0.83) and 18% lower ICU admission (p=0.75). RCT 186 hospitalized COVID-19 patients showing no significant differences with oral amantadine compared to placebo.
Nov 30
2022
 Chober et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2022.09.026 Improved survival in intensive care unit in severe COVID-19 associated with amantadine use - retrospective study
Retrospective 241 COVID-19 ICU patients requiring mechanical ventilation showing significantly lower mortality with intravenous amantadine. However the KM plot shows very high control deaths on day 1 and no treatment deaths days 2-4. Give..