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Cannabichromene for COVID-19

Cannabichromene has been reported as potentially beneficial for treatment of COVID-19. We have not reviewed these studies. See all other treatments.
Schadich et al., Secondary metabolite profiles and anti‐SARS‐CoV‐2 activity of ethanolic extracts from nine genotypes of Cannabis sativa L., Archiv der Pharmazie, doi:10.1002/ardp.202400607
AbstractThis study deals with the comprehensive phytochemical composition and antiviral activity against SARS‐CoV‐2 of acidic (non‐decarboxylated) and neutral (decarboxylated) ethanolic extracts from seven high‐cannabidiol (CBD) and two high‐Δ9‐tetrahydrocannabinol (Δ9‐THC) Cannabis sativa L. genotypes. Their secondary metabolite profiles, phytocannabinoid, terpenoid, and phenolic, were determined by LC‐UV, GC‐MS, and LC‐MS/MS analyses, respectively. All three secondary metabolite profiles, cannabinoid, terpenoid, and phenolic, varied significantly among cannabinoid extracts of different genotypes. The dose–response analyses of their antiviral activity against SARS‐CoV‐2 showed that only the single predominant phytocannabinoids (CBD or THC) of the neutral extracts exhibited antiviral activity (all IC50 < 10.0 μM). The correlation matrix between phytoconstituent levels and antiviral activity revealed that the phenolic acids, salicylic acid and its glucoside, chlorogenic acid, and ferulic acid, and two flavonoids, abietin, and luteolin, in different cannabinoid extracts from high‐CBD genotypes are implicated in the genotype‐distinct antagonistic effects on the predominant phytocannabinoid. On the other hand, these analyses also suggested that the other phytocannabinoids and the flavonoid orientin can enrich the extract's pharmacological profiles. Thus, further preclinical studies on cannabinoid extract formulations with adjusted non‐phytocannabinoid compositions are warranted to develop supplementary antiviral treatments.
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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