Dihydropyrimidine-2-thione 12j for COVID-19

Dihydropyrimidine-2-thione 12j has been reported as potentially beneficial for COVID-19 in the following study.

COVID-19 involves the interplay of 350+ viral and host proteins and factors providing many therapeutic targets. Scientists have proposed 10,000+ potential treatments. c19early.org analyzes 200+ treatments. We have not reviewed dihydropyrimidine-2-thione 12j in detail.

Study suggesting benefit with dihydropyrimidine-2-thione 12j

Saeed et al., Dihydropyrimidine-2-thione derivatives as SARS-CoV-2 main protease inhibitors: synthesis, SAR and in vitro profiling, RSC Advances, doi:10.1039/d4ra08449g

Despite the passage of approximately five years since the outbreak, an efficacious remedy for SARS-CoV-2 remains elusive, highlighting the urgent imperative for developing SARS-CoV-2 potent inhibitors.