Conv. Plasma
Nigella Sativa

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Morphine for COVID-19

Morphine has been reported as potentially beneficial for treatment of COVID-19. We have not reviewed these studies. See all other treatments.
Syamsi et al., Efek Potensial Moringa Oleifera pada Infeksi COVID-19, Malahayati Nursing Journal, doi:10.33024/mnj.v5i3.8144
ABSTRACT The COVID 19 pandemic is an outbreak caused by the coronavirus disease 2019 (COVID-19) with clinical manifestations of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which has caused a large number of deaths worldwide. The most common complications of COVID-19 are cardiovascular and kidney disorders. The urgency to develop natural medicines with natural ingredients that are effective against COVID-19 is very important to maintain body immunity and at the same time protect the body from close contact with sufferers of COVID-19. Moringa plants have the potential to increase the body's resistance (immune booster) of sufferers against SARS-CoV-2. (COVID-19) and moringa plants have other health functions such as anti-inflammatory, antimicrobial, antidiabetic, antioxidant, antitumor, anticancer, antihypertensive, antiasthma, anticoagulation, antiurolithiasis, anthelmintic, antifertility, antihyperthyroid, and antialzheimer's. Several components of Moringa that play a role in the antiviral COVID-19 are Kaempferol, Pterygospermin, Morphine, Quercetin, and Apigenin-7-O-rutinoside. This Literature Review provides a basis for further research on the development of clinical applications of Moringa Oleifera for the treatment of SARS-CoV-2. Keywords: Covid-19, Potential Effects, Literature Review ABSTRAK Pandemi COVID 19 adalah wabah yang disebabkan penyakit coronavirus 2019 (COVID-19) dengan manisfestasi klinis sindrom pernapasan akut coronavirus 2 (SARS-CoV-2) yang menyebabkan kematian yang cukup besar di seluruh dunia. Komplikasi tersering COVID-19 adalah gangguan kardiovaskular dan ginjal. Urgensi mengembangkan pengobatan natural bahan alam yang mempunyai efektivitas terhadap COVID 19 menjadi sangat penting untuk menjaga imunitas tubuh dan sekaligus menjaga tubuh terhadap kontak erat penderita COVID 19. Tanaman kelor mempunyai potensi meningkatkan daya tahan tubuh (booster imun )penderita terhadap penyakit SARS-CoV-2 (COVID 19) dan tanaman kelor memiliki fungsi Kesehatan lainnya seperti antiradang, antimikroba, antidiabetes, antioksidan, antitumor, antikanker, antihipertensi, antiasma, antikoagulasi, antiurolitiasis, anthelmintik, antifertilitas, antihipertiroid, dan antialzheimer. Beberapa komponen kelor yang berperan pada antivirus COVID-19 adalah Kaempferol, Pterygospermin, Morfin, Quercetin, dan Apigenin-7-O-rutinoside. Tinjauan Pustaka ini memberikan dasar untuk penelitian lebih lanjut pengembangan aplikasi klinis Moringa Oleifera untuk pengobatan SARS-CoV-2. Kata Kunci: Covid-19, Efek Potensial, Tinjauan Pustaka
Wei et al., Total network controllability analysis discovers explainable drugs for Covid-19 treatment, Biology Direct, doi:10.1186/s13062-023-00410-9
Abstract Background The active pursuit of network medicine for drug repurposing, particularly for combating Covid-19, has stimulated interest in the concept of structural controllability in cellular networks. We sought to extend this theory, focusing on the defense rather than control of the cell against viral infections. Accordingly, we extended structural controllability to total structural controllability and introduced the concept of control hubs. Perturbing any control hub may render the cell uncontrollable by exogenous stimuli like viral infections, so control hubs are ideal drug targets. Results We developed an efficient algorithm to identify all control hubs, applying it to a largest homogeneous network of human protein interactions, including interactions between human and SARS-CoV-2 proteins. Our method recognized 65 druggable control hubs with enriched antiviral functions. Utilizing these hubs, we categorized potential drugs into four groups: antiviral and anti-inflammatory agents, drugs acting on the central nervous system, dietary supplements, and compounds enhancing immunity. An exemplification of our approach’s effectiveness, Fostamatinib, a drug initially developed for chronic immune thrombocytopenia, is now in clinical trials for treating Covid-19. Preclinical trial data demonstrated that Fostamatinib could reduce mortality rates, ICU stay length, and disease severity in Covid-19 patients. Conclusions Our findings confirm the efficacy of our novel strategy that leverages control hubs as drug targets. This approach provides insights into the molecular mechanisms of potential therapeutics for Covid-19, making it a valuable tool for interpretable drug discovery. Our new approach is general and applicable to repurposing drugs for other diseases.
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