Quercetin-3-O-glucuronide for COVID-19

 Quercetin-3-O-glucuronide has been reported as potentially beneficial for COVID-19 in the following studies.
COVID-19 involves the interplay of 350+ viral and host proteins and factors providing many therapeutic targets. Scientists have proposed 10,000+ potential treatments. c19early.org analyzes 200+ treatments. We have not reviewed quercetin-3-O-glucuronide in detail.
Spiegel et al., Primary Antioxidant Power and Mpro SARS‐CoV‐2 Non‐Covalent Inhibition Capabilities of Miquelianin, Chemistry – An Asian Journal, doi:10.1002/asia.202400079
AbstractThe antioxidant power of quercetin‐3‐O‐glucuronide (miquelianin) has been studied, at the density functional level of theory, in both lipid‐like and aqueous environments. In the aqueous phase, the computed pKa equilibria allowed the identification of the neutral and charged species present in solution that can react with the ⋅OOH radical. The Hydrogen Atom Transfer (HAT), Single Electron Transfer (SET) and Radical Adduct Formation (RAF) mechanisms were considered, and the individual, total and fraction corrected rate constants were obtained. Potential non‐covalent inhibition of Mpro from SARS‐CoV‐2 by miquelianin has been also evaluated.
Khelef et al., Artemisia campestris L. as a Promising Source of Potential Antiviral Drugs for SARS-CoV-2: Docking and Dynamic Simulation Studies, Scientific African, doi:10.1016/j.sciaf.2024.e02445
Rani et al., Modern drug discovery applications for the identification of novel candidates for COVID-19 infections, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.104125