T-cinamic acid for COVID-19

 T-cinamic acid has been reported as potentially beneficial for COVID-19 in the following study.
COVID-19 involves the interplay of 350+ viral and host proteins and factors providing many therapeutic targets. Scientists have proposed 10,000+ potential treatments. c19early.org analyzes 210+ treatments. We have not reviewed t-cinamic acid in detail.
Kaya et al., Phytochemical Profiling and in Vitro Anti-Sars-Cov-2 Evaluation of Verbascum Zerdust: Integration of Ace2-Spike Inhibition Assay and Computational Approaches, Bitlis Eren University Journal of Science and Technology, doi:10.17678/beuscitech.1725713
Plants have long been used to protect and maintain human health. Due to the increasing costs and side effects of synthetic drugs, interest in herbal products is increasing day by day. For this reason, research continues in laboratories around the world to discover new drug active ingredients of natural origin. In the present study, the COVID-19 Spike ACE2 binding inhibition capacity of Verbascum zerdust Fırat was studied using commercial kits. In addition, the plant content was determined by HPLC-DAD analysis and the interaction of the components in the plant content with the 7U0N protein was determined by molecular docking analysis. In addition, the ADME profiles of the molecules detected in the plant content were determined using the SwissADME web tool. According to the results obtained, Verbascum zerdust showed the highest inhibition value at 0.001µl concentration (15.38%). In molecular docking analysis, catechin carbohydrate showed the highest binding affinity to the 7U0N complex (∆G= -8.3 kcal/mol). Among the molecules detected in the plant extract, catechin hydrate, resveretrol, quercetin and t-cinamic acid fully complied with the Lipinski, Ghose, Veber, Egan and Muegge criteria. In conclusion, the results obtained indicate that Verbascum zerdust plant can be used in the treatment of COVID-19.