Promethazine for COVID-19
Promethazine has been reported as potentially beneficial for treatment of COVID-19. We have not reviewed these studies. See all other treatments.
Broad Anti-coronavirus Activity of Food and Drug Administration-Approved Drugs against SARS-CoV-2 In Vitro and SARS-CoV In Vivo, Journal of Virology, doi:10.1128/jvi.01218-20 ,
There are no FDA-approved antivirals for any coronavirus, including SARS-CoV-2. Numerous drugs are already approved for human use that may have antiviral activity and therefore could potentially be rapidly repurposed as antivirals. Here, we present data assessing the antiviral activity of 20 FDA-approved drugs against SARS-CoV-2 that also inhibit SARS-CoV and MERS-CoV in vitro . We found that 17 of these inhibit SARS-CoV-2, suggesting that they may have pan-anti-coronaviral activity. We directly followed up seven of these and found that they all inhibit infectious-SARS-CoV-2 production. Moreover, we evaluated chloroquine and chlorpromazine in vivo using mouse-adapted SARS-CoV. We found that neither drug inhibited viral replication in the lungs, but both protected against clinical disease.
Repurposing Screens of FDA-Approved Drugs Identify 29 Inhibitors of SARS-CoV-2, Journal of Microbiology and Biotechnology, doi:10.4014/jmb.2009.09009 ,
Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia, Nature, doi:10.1038/s41586-021-03491-6 ,
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