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MAS825 for COVID-19: real-time analysis

c19early.org

MAS825 for COVID-19

1 study with 138 patients

Serious outcome risk

MAS825

Control

No significant improvements are seen in meta-analysis to date.

COVID-19 MAS825 studies · November 2026

Outcome (studies)

Improvement

Relative risk · 95% CI

All studies (1)−16%

Mortality (1)−16%

RCTs (1)−16%

Late (1)−16%

00.511.5+

← MAS825
reduces riskIncreased
risk →

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Jun 20 2023	Hakim et al., Clinical and Experimental Immunology, doi:10.1093/cei/uxad065	Efficacy and safety of MAS825 (anti-IL-1β/IL-18) in COVID-19 patients with pneumonia and impaired respiratory function
Jun 20 2023	16% higher mortality (p=0.59) and 7% worse recovery (p=0.7). RCT 138 hospitalized COVID-19 patients with pneumonia showing no significant difference in mortality or APACHE II scores with MAS825 (anti-IL-1β/IL-18 monoclonal antibody) compared to placebo.

Most accessed treatments

Antiviral effects

Vitamins & Minerals

Host endosomal entry / trafficking

Dual-action mAbs

RdRp

Nasal & Oral Sprays / Rinses

Analgesics

Antiandrogens

Host targets and pathways

Inflammatory and immune modulation

Mpro (Gen 1)

Oxidative stress and cytoprotection

Lifestyles

TMPRSS2

Spike neutralization

Replication inhibition (target unresolved)

COVID-19 mAbs

Pleiotropic modulation

Attachment / entry inhibition

Mpro (Gen 2)

H1RAs

Nutrients and microbiome support

Host mAbs

IL-6 / IL-6R blockade

Physical and extracorporeal interventions

Natural products and extracts

Symptom management

Unconfirmed antiviral rationale

Lifestyle, behaviors, and exposure prevention

Other complication management

Mpro / 3CLpro

Host pyrimidine synthesis

Direct viral inactivation

Endothelial / vascular protection

Direct respiratory tract treatments

Other antibodies, proteins, peptides, cells, and RNA therapies

Secondary infection and coinfection management

MAS825 for COVID-19: real-time analysis