MAC-5576 for COVID-19

 MAC-5576 has been reported as potentially beneficial for COVID-19 in the following studies.
COVID-19 involves the interplay of 350+ viral and host proteins and factors providing many therapeutic targets. Scientists have proposed 10,000+ potential treatments. c19early.org analyzes 200+ treatments. We have not reviewed MAC-5576 in detail.
Atatreh et al., Exploring covalent inhibitors of SARS-CoV-2 main protease: from peptidomimetics to novel scaffolds, Journal of Enzyme Inhibition and Medicinal Chemistry, doi:10.1080/14756366.2025.2460045
Pang et al., The research progress of SARS-CoV-2 main protease inhibitors from 2020 to 2022, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115491