REGN17092 for COVID-19
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COVID-19 Treatment Clinical Evidence
COVID-19 involves the interplay of 400+ viral and host proteins and factors, providing many therapeutic targets.
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Only three high-profit early treatments are approved in the US.
In reality, many treatments reduce risk,
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Naso/
oropharyngeal treatment Effective Treatment directly to the primary source of initial infection. -
Healthy lifestyles Protective Exercise, sunlight, a healthy diet, and good sleep all reduce risk.
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Immune support Effective Vitamins A, C, D, and zinc show reduced risk, as with other viruses.
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Thermotherapy Effective Methods for increasing internal body temperature, enhancing immune system function.
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Systemic agents Effective Many systemic agents reduce risk, and may be required when infection progresses.
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High-profit systemic agents Conditional Effective, but with greater access and cost barriers.
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Monoclonal antibodies Limited Utility Effective but rarely used—high cost, variant dependence, IV/SC admin.
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Acetaminophen Harmful Increased risk of severe outcomes and mortality.
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Remdesivir Harmful Increased mortality with longer followup. Increased kidney and liver injury, cardiac disorders.
REGN17092 may be beneficial for
COVID-19 according to the study below.
COVID-19 involves the interplay of 400+ viral and host proteins and factors providing many therapeutic targets.
Scientists have proposed 11,000+ potential treatments.
c19early.org analyzes
210+ treatments.
We have not reviewed REGN17092 in detail.
, P-1605. A Phase 1, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of REGN17092, an YTE modified Anti-SARS-COV-2 (COVID-19) Monoclonal Antibody in Adult Healthy Volunteers, Open Forum Infectious Diseases, doi:10.1093/ofid/ofaf695.1784
Abstract Background REGN17092 is a human IgG 1 monoclonal antibody which includes a YTE modification in the Fc portion to extend the half-life. It targets severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods This study is a randomized, double-blind, placebo-controlled, single ascending dose study to evaluate the safety, tolerability and pharmacokinetics of REGN17092 in healthy subjects (18-60 yrs of age). The study consisted of 5 study cohorts evaluating intravenous (lV) dosing (300mg, 1200mg and 2400mg) and subcutaneous (SC) dosing (300mg and 1200mg) of REGN17092. The primary end point was safety and tolerability. Secondary end points included pharmacokinetics and anti-drug antibodies. Results Between Nov 2023 and Feb 2024, a total of 78 participants screened; 40 subjects were randomized. Clinical adverse events were reported by 34/40 (85%) subjects. Most frequently reported adverse events, assessed as related by the investigator, in ≥3 participants included injection site reactions (ISR) (17.5%) and headache (10%).). Most clinical adverse events were mild to moderate in intensity. Infusion related reactions (all mild) occurred in 9 subjects (4 headache, 2 diastolic hypotension, 1 blood pressure increase, 1 dysgeusia, 1 migraine). Injection site reactions (all mild) occurred in 13 subjects. Most frequent injection site reaction symptoms reported include erythema, edema and pain. There were 2 serious adverse events (atrial fibrillation and cholecystectomy), neither were deemed related to investigational product. The REGN17092 exhibited an extended half-life of greater than 70 days. Conclusion REGN17092 is well tolerated in healthy adults. The pharmacokinetic analyses suggest the REGN17092 maintains high plasma concentrations for several months after a single subcutaneous administration. Disclosures Flonza Isa, MD, Regeneron Pharmaceuticals, Inc.: Stocks/Bonds (Public Company) Ashley Sconzo, MS, Regeneron Pharmaceuticals, Inc.: Stocks/Bonds (Public Company) Yogesh Patel, PhD, Regeneron Pharmaceuticals, Inc.: Stocks/Bonds (Public Company) Maria Rosario, PhD, Regeneron Pharmaceuticals, Inc.: Stocks/Bonds (Public Company) Kenneth C. Turner, PhD, Regeneron Pharmaceuticals, Inc.: Stocks/Bonds (Public Company) Oleg Milberg, PhD, Regeneron Pharmaceuticals, Inc.: Stocks/Bonds (Public Company) Ana Gonzalez Ortiz, MD, PhD, Regeneron Pharmaceuticals, Inc.: Stocks/Bonds (Public Company) Lori Faria, BS, Regeneron Pharmaceuticals, Inc.: Stocks/Bonds (Public Company) Ingeborg Heirman, PhD, Regeneron Pharmaceuticals, Inc.: Stocks/Bonds (Public Company) Alina Baum, PhD, Regeneron..