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Danicopan for COVID-19: real-time analysis

c19early.org

Danicopan for COVID-19

1 study with 201 patients

Serious outcome risk

Danicopan

Control

COVID-19 Danicopan studies · November 2026

Outcome (studies)

Improvement

Relative risk · 95% CI

All studies (1)−43%

Mortality (1)−43%

Hospitalization (1)−19%

RCTs (1)−43%

Late (1)−43%

00.511.5+

← Danicopan
reduces riskIncreased
risk →

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Apr 23 2022	Beigel et al., NCT04988035	ACTIV-5 / Big Effect Trial (BET-C) for the Treatment of COVID-19
Apr 23 2022	43% higher mortality (p=0.34), 17% higher ventilation (p=0.69), 54% worse recovery (p=0.01), and 37% worse improvement (p=0.06). RCT 201 hospitalized COVID-19 patients showing increased risk with danicopan treatment, with statistical significance for time to sustained recovery.

Most accessed treatments

Antiviral effects

Vitamins & Minerals

Host endosomal entry / trafficking

Dual-action mAbs

RdRp

Nasal & Oral Sprays / Rinses

Analgesics

Antiandrogens

Host targets and pathways

Inflammatory and immune modulation

Mpro (Gen 1)

Oxidative stress and cytoprotection

Lifestyles

TMPRSS2

Spike neutralization

Replication inhibition (target unresolved)

COVID-19 mAbs

Pleiotropic modulation

Attachment / entry inhibition

Mpro (Gen 2)

H1RAs

Nutrients and microbiome support

Host mAbs

IL-6 / IL-6R blockade

Physical and extracorporeal interventions

Natural products and extracts

Symptom management

Unconfirmed antiviral rationale

Lifestyle, behaviors, and exposure prevention

Other complication management

Mpro / 3CLpro

Host pyrimidine synthesis

Direct viral inactivation

Endothelial / vascular protection

Direct respiratory tract treatments

Other antibodies, proteins, peptides, cells, and RNA therapies

Secondary infection and coinfection management

Danicopan for COVID-19: real-time analysis