MAb P7 for COVID-19
c19early.org
COVID-19 Treatment Clinical Evidence
COVID-19 involves the interplay of 400+ viral and host proteins and factors, providing many therapeutic targets.
c19early analyzes 6,000+ studies for 210+ treatments—over 17 million hours of research.
Only three high-profit early treatments are approved in the US.
In reality, many treatments reduce risk,
with 25 low-cost treatments approved across 163 countries.
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Naso/
oropharyngeal treatment Effective Treatment directly to the primary source of initial infection. -
Healthy lifestyles Protective Exercise, sunlight, a healthy diet, and good sleep all reduce risk.
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Immune support Effective Vitamins A, C, D, and zinc show reduced risk, as with other viruses.
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Thermotherapy Effective Methods for increasing internal body temperature, enhancing immune system function.
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Systemic agents Effective Many systemic agents reduce risk, and may be required when infection progresses.
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High-profit systemic agents Conditional Effective, but with greater access and cost barriers.
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Monoclonal antibodies Limited Utility Effective but rarely used—high cost, variant dependence, IV/SC admin.
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Acetaminophen Harmful Increased risk of severe outcomes and mortality.
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Remdesivir Harmful Increased mortality with longer followup. Increased kidney and liver injury, cardiac disorders.
MAb P7 may be beneficial for
COVID-19 according to the study below.
COVID-19 involves the interplay of 400+ viral and host proteins and factors providing many therapeutic targets.
Scientists have proposed 11,000+ potential treatments.
c19early.org analyzes
210+ treatments.
We have not reviewed mAb P7 in detail.
, An ultra-long heavy chain bovine antibody neutralizes SARS-CoV-2 and reacts
broadly with sarbecoviruses, bioRxiv, doi:10.1101/2025.01.03.631215
Abstract The threat of emergence of further SARS-CoV-2 variants, and the future spillover potential of other sarbecoviruses has prompted continued efforts to isolate broadly reactive monoclonal antibodies for therapeutic use. In this study, we generated monoclonal antibodies from immunised cattle, primarily because of their ability to produce antibodies with ultra-long heavy chain complementarity determining region 3 (CDRH3) domains. Such antibodies have been shown to have potent and cross-reactive neutralisation phenotypes in other virus infections. Following extended immunisation with different forms of spike protein and using single B-cell sorting and phage display techniques, we isolated 33 mAbs, including 10 with ultra-long CDRH3s (>50 amino acids). Of these, mAbs P7 and 99 exhibited remarkable neutralisation breadth and potency. Notably, mAb P7, which possessed an ultra-long CDRH3, neutralised all tested variants, including SARS-CoV-1, with IC50values ranging from 0.01 µg/mL to 1.06 µg/mL. This antibody was also cross-reactive against a panel of RBDs from diverse sarbecovirus species. Structural studies revealed that mAb 99 targets a region of the receptor-binding domain (RBD) of the spike protein that overlaps with the ACE2 binding site. Although the structure of the P7 Fab-RBD complex was not resolvable, data suggest P7 induces trimer dissociation by binding to an occluded RBD epitope, likely mediated by the extended CDRH3 structure. Syrian hamster challenge experiments, using several VOCs, showed that mAbs P7 and 99 significantly reduced lung viral load. These findings highlight the potential of bovine-derived, especially those possessing ultra-long CDRH3s, as effective therapeutics against current and future sarbecovirus threats. One Sentence Summary Monoclonal antibodies derived from SARS-CoV-2 immunised cows exhibit pan-sarbecovirus reactivity, highlighting their potential use as therapeutics