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Nicotine for COVID-19
1 study with 213 patients
Hospital Icon Control
Hospital Icon Nicotine Serious Outcome Risk
No significant improvements are seen in meta analysis to date.
COVID-19 Nicotine studies. Nov 2025. c19early.org
0 0.5 1 1.5+ All studies -5% Mortality -5% RCTs -5% Late -5% Favorsnicotine Favorscontrol
Jun 9
2022
 Labro et al., Intensive Care Medicine, doi:10.1007/s00134-022-06721-1 Nicotine patches in patients on mechanical ventilation for severe COVID-19: a randomized, double-blind, placebo-controlled, multicentre trial
5% higher mortality (p=0.78) and 6% higher progression (p=1). RCT 218 critically ill COVID-19 patients showing no benefit of transdermal nicotine patches. The trial tested a hypothesis that emerged early in the pandemic based on observations of lower COVID-19 rates among smokers, however alternative..