Gabapentin for COVID-19: real-time analysis of 2 studies

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c19early.org

Gabapentin for COVID-19

1 study with 129 patients

Serious outcome risk

Gabapentin

Control

COVID-19 Gabapentin studies · October 2026

Outcome (studies)

Improvement

Relative risk · 95% CI

All studies (1)−11%

Hospitalization (1)−11%

RCTs (1)−11%

Late (1)−11%

00.511.5+

← Gabapentin
reduces riskIncreased
risk →

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Aug 31 2025	Pan et al., Biomedicines, doi:10.3390/biomedicines13092133	CX3CR1–TLR4 Axis as a Shared Neuroimmune Target in COVID-19 and Epilepsy: Integrative Transcriptomics and Gabapentin Repositioning
	In silico study showing that gabapentin may be beneficial for COVID-19 treatment through shared neuroinflammatory pathways with epilepsy. Authors performed integrative transcriptomic analysis of COVID-19 peripheral blood mononuclear cells..
Jul 31 2022	Soltani et al., The Clinical Respiratory Journal, doi:10.1111/crj.13529	The effectiveness of gabapentin and gabapentin/montelukast combination compared with dextromethorphan in the improvement of COVID‐19‐ related cough: A randomized, controlled clinical trial
	11% longer hospitalization (p=0.23) and 97% worse recovery (p<0.0001). RCT 180 hospitalized COVID-19 patients showing improved cough symptoms and shorter hospitalization with montelukast/gabapentin compared to gabapentin. For gabapentin vs. dextromethorphan there was no significant difference in hospitalizat..