Elderberry for COVID-19: real-time analysis of 2 studies

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c19early.org

Elderberry for COVID-19

1 study with 171 patients

No significant improvements are seen in meta-analysis to date.

COVID-19 Elderberry studies · October 2026

Outcome (studies)

Improvement

Relative risk · 95% CI

All studies (1)−1%

RCTs (1)−1%

Early (1)−1%

00.511.5+

← Elderberry
reduces riskIncreased
risk →

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Elderberry (Sambucus nigra) is an orally administered botanical dietary supplement proposed as potentially beneficial for SARS-CoV-2 via antiviral and immunomodulatory mechanisms. Recent:

Setz.


Apr 10	Setz et al., Nutrients, doi:10.3390/nu18081205	Synergistic Virus Neutralizing Activities of European Black Elderberry Fruit Extract and Iota-Carrageenan Against SARS-CoV-2, Influenza A Virus and Respiratory Syncytial Virus
	In vitro study showing synergistic antiviral activity of black elderberry fruit extract and iota-carrageenan against SARS-CoV-2 Omicron, influenza A, and respiratory syncytial virus.
May 16 2022	Evans et al., NCT05489770	A Randomised, Single Blinded Study Investigating the Role of ' Black Elderberry (Sambucus Nigra) (Sambucol®) in the Treatment, Progression and Reduction of Symptoms in Participants With Coronavirus 19
	1% worse recovery (p=0.37). RCT 204 COVID-19 patients showing no significant differences with Sambucol® black elderberry (Sambucus nigra) treatment. Treatment delay is unknown and may be too late. There was no restriction on the time from symptom onset, patients onl..