Astegolimab for COVID-19: real-time analysis

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c19early.org

Astegolimab for COVID-19

1 study with 264 patients

Serious outcome risk

Astegolimab

Control

No significant improvements are seen in meta-analysis to date.

COVID-19 Astegolimab studies · October 2026

Outcome (studies)

Improvement

Relative risk · 95% CI

All studies (1)−31%

Mortality (1)−31%

RCTs (1)−31%

Late (1)−31%

00.511.5+

← Astegolimab
reduces riskIncreased
risk →

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Nov 14 2022	Waters et al., Critical Care Medicine, doi:10.1097/CCM.0000000000005716	Astegolimab or Efmarodocokin Alfa in Patients With Severe COVID-19 Pneumonia: A Randomized, Phase 2 Trial
Nov 14 2022	31% higher mortality (p=0.41) and 1% improved recovery (p=0.95). RCT 396 hospitalized patients with severe COVID-19 pneumonia showing no significant difference in time to recovery with astegolimab (IL-33 receptor blocker) or efmarodocokin alfa (IL-22 pathway activator). Median time to recovery was 11 d..