Pterodontic acid for COVID-19

 Pterodontic acid has been reported as potentially beneficial for COVID-19 in the following study.
COVID-19 involves the interplay of 350+ viral and host proteins and factors providing many therapeutic targets. Scientists have proposed 10,000+ potential treatments. c19early.org analyzes 200+ treatments. We have not reviewed pterodontic acid in detail.
Srivastava et al., Identification of putative antiviral bioactive compounds derived from family Asteraceae: An in silico approach, Journal of Cellular Biochemistry, doi:10.1002/jcb.30538
AbstractThis computational study investigates 21 bioactive compounds from the Asteraceae family as potential inhibitors targeting the Spike protein (S protein) of SARS‐CoV‐2. Employing in silico methods and simulations, particularly CDOCKER and MM‐GBSA, the study identifies two standout compounds, pterodontic acid and cichoric acid, demonstrating robust binding affinities (−46.1973 and −39.4265 kcal/mol) against the S protein. Comparative analysis with Favipiravir underscores their potential as promising inhibitors. Remarkably, these bioactives exhibit favorable ADMET properties, suggesting safety and efficacy. Molecular dynamics simulations validate their stability and interactions, signifying their potential as effective SARS‐CoV‐2 inhibitors.